4d0g: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structure of Rab14 in complex with Rab-Coupling Protein (RCP)==

~~The entry~~ 4d0g is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4d0g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D0G FirstGlance]. <br>

~~Authors~~: ~~Lall~~, P., ~~Khan~~, A.R.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d0g RCSB], [http://www.ebi.ac.uk/pdbsum/4d0g PDBsum]</span></td></tr>

~~Description~~: ~~Structure of Rab14~~ in complex ~~with Rab~~-~~Coupling Protein~~ (~~RCP~~)

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[http://www.uniprot.org/uniprot/RAB14_HUMAN RAB14_HUMAN]] Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.<ref>PMID:22595670</ref> [[http://www.uniprot.org/uniprot/RFIP1_HUMAN RFIP1_HUMAN]] A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.<ref>PMID:11786538</ref> <ref>PMID:15181150</ref> <ref>PMID:15355514</ref> <ref>PMID:16920206</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Khan, A R]]

[[Category: Lall, P]]

[[Category: ~~Khan, A.R~~]]

[[Category: Effector recruitment]]

[[Category: Endosomal trafficking]]

[[Category: Hydrolase]]

[[Category: Rab14 gtpase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structure of Rab14 in complex with Rab-Coupling Protein (RCP)==
+<StructureSection load='4d0g' size='340' side='right' caption='[[4d0g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-The entry 4d0g is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4d0g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D0G FirstGlance]. <br>
-Authors: Lall, P., Khan, A.R.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d0g RCSB], [http://www.ebi.ac.uk/pdbsum/4d0g PDBsum]</span></td></tr>
-Description: Structure of Rab14 in complex with Rab-Coupling Protein (RCP)
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/RAB14_HUMAN RAB14_HUMAN]] Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.<ref>PMID:22595670</ref>  [[http://www.uniprot.org/uniprot/RFIP1_HUMAN RFIP1_HUMAN]] A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.<ref>PMID:11786538</ref> <ref>PMID:15181150</ref> <ref>PMID:15355514</ref> <ref>PMID:16920206</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Khan, A R]]
 [[Category: Lall, P]]
-[[Category: Khan, A.R]]
+[[Category: Effector recruitment]]
+[[Category: Endosomal trafficking]]
+[[Category: Hydrolase]]
+[[Category: Rab14 gtpase]]