4yub: Difference between revisions
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''' | ==Crystal structure of human Nicotinic Acid Phosphoribosyltransferase== | ||
<StructureSection load='4yub' size='340' side='right' caption='[[4yub]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4yub]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YUB FirstGlance]. <br> | |||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate_phosphoribosyltransferase Nicotinate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.21 6.3.4.21] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yub OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yub RCSB], [http://www.ebi.ac.uk/pdbsum/4yub PDBsum]</span></td></tr> | |||
</table> | |||
[[ | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/PNCB_HUMAN PNCB_HUMAN]] Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.<ref>PMID:17604275</ref> Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Nicotinate phosphoribosyltransferase]] | |||
[[Category: Garavaglia, S]] | [[Category: Garavaglia, S]] | ||
[[Category: Marletta, A S]] | |||
[[Category: Rizzi, M]] | [[Category: Rizzi, M]] | ||
[[Category: Fk866 recycling]] | |||
[[Category: Ligase]] | |||
[[Category: Nad biosynthesis]] | |||
[[Category: Nad pathway]] | |||
[[Category: Nicotinic acid preiss handler pathway]] | |||
[[Category: Phosphoribosyl transferase]] | |||
Revision as of 12:20, 20 May 2015
Crystal structure of human Nicotinic Acid Phosphoribosyltransferase
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