3aid: Difference between revisions

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[[Image:3aid.gif|left|200px]]<br /><applet load="3aid" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:3aid.gif|left|200px]]
caption="3aid, resolution 2.5&Aring;" />
 
'''A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE'''<br />
{{Structure
|PDB= 3aid |SIZE=350|CAPTION= <scene name='initialview01'>3aid</scene>, resolution 2.5&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ARQ:BENZOYLAMINO-BENZYL-METHYL-[2-HYDROXY-3-[1-METHYL-ETHYL-OXY-N-FORMAMIDYL]-4-PHENYL-BUTYL]-AMMONIUM'>ARQ</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
3AID is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus] with <scene name='pdbligand=ARQ:'>ARQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AID OCA].  
3AID is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AID OCA].  


==Reference==
==Reference==
A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere., Rutenber EE, McPhee F, Kaplan AP, Gallion SL, Hogan JC Jr, Craik CS, Stroud RM, Bioorg Med Chem. 1996 Sep;4(9):1545-58. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8894111 8894111]
A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere., Rutenber EE, McPhee F, Kaplan AP, Gallion SL, Hogan JC Jr, Craik CS, Stroud RM, Bioorg Med Chem. 1996 Sep;4(9):1545-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8894111 8894111]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus]]
[[Category: Human immunodeficiency virus]]
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[[Category: protease]]
[[Category: protease]]


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