2moc: Difference between revisions

Revision as of 15:55, 27 May 2015

Membrane induced structure of novel human tachykinin Hemokinin-1 (hHK1)

Structural highlights

2moc is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[TKN4_HUMAN] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.^[1] ^[2] ^[3] ^[4]

References

↑ Page NM, Bell NJ, Gardiner SM, Manyonda IT, Brayley KJ, Strange PG, Lowry PJ. Characterization of the endokinins: human tachykinins with cardiovascular activity. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6245-50. Epub 2003 Apr 25. PMID:12716968 doi:https://dx.doi.org/10.1073/pnas.0931458100
↑ Yoshioka D, Takebuchi F, Nishimori T, Naono R, Ikeda T, Nakayama T. Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat. Neurosci Lett. 2006 Dec 27;410(3):193-7. Epub 2006 Nov 13. PMID:17101218 doi:https://dx.doi.org/10.1016/j.neulet.2006.09.024
↑ Ravina CG, Seda M, Pinto FM, Orea A, Fernandez-Sanchez M, Pintado CO, Candenas ML. A role for tachykinins in the regulation of human sperm motility. Hum Reprod. 2007 Jun;22(6):1617-25. Epub 2007 Apr 16. PMID:17437961 doi:https://dx.doi.org/dem069
↑ Naono R, Nakayama T, Ikeda T, Matsushima O, Nishimori T. Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. Brain Res. 2007 Aug 24;1165:71-80. Epub 2007 Jul 3. PMID:17655832 doi:https://dx.doi.org/S0006-8993(07)01265-6

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OCA

[1] Page NM, Bell NJ, Gardiner SM, Manyonda IT, Brayley KJ, Strange PG, Lowry PJ. Characterization of the endokinins: human tachykinins with cardiovascular activity. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6245-50. Epub 2003 Apr 25. PMID:12716968 doi:https://dx.doi.org/10.1073/pnas.0931458100

[2] Yoshioka D, Takebuchi F, Nishimori T, Naono R, Ikeda T, Nakayama T. Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat. Neurosci Lett. 2006 Dec 27;410(3):193-7. Epub 2006 Nov 13. PMID:17101218 doi:https://dx.doi.org/10.1016/j.neulet.2006.09.024

[3] Ravina CG, Seda M, Pinto FM, Orea A, Fernandez-Sanchez M, Pintado CO, Candenas ML. A role for tachykinins in the regulation of human sperm motility. Hum Reprod. 2007 Jun;22(6):1617-25. Epub 2007 Apr 16. PMID:17437961 doi:https://dx.doi.org/dem069

[4] Naono R, Nakayama T, Ikeda T, Matsushima O, Nishimori T. Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. Brain Res. 2007 Aug 24;1165:71-80. Epub 2007 Jul 3. PMID:17655832 doi:https://dx.doi.org/S0006-8993(07)01265-6

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Membrane induced structure of novel human tachykinin Hemokinin-1 (hHK1)==
+<StructureSection load='2moc' size='340' side='right' caption='[[2moc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-The entry 2moc is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2moc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MOC FirstGlance]. <br>
-Authors: Ganjiwale, A., Cowsik, S.
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2moc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2moc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2moc RCSB], [http://www.ebi.ac.uk/pdbsum/2moc PDBsum]</span></td></tr>
+</table>
-Description: Membrane induced structure of novel human tachykinin Hemokinin-1 (hHK1)
+== Function ==
-[[Category: Unreleased Structures]]
+[[http://www.uniprot.org/uniprot/TKN4_HUMAN TKN4_HUMAN]] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.<ref>PMID:12716968</ref> <ref>PMID:17101218</ref> <ref>PMID:17437961</ref> <ref>PMID:17655832</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Cowsik, S]]
 [[Category: Ganjiwale, A]]
+[[Category: Neuropeptide]]
+[[Category: Tachykinin]]

2moc: Difference between revisions

Revision as of 15:55, 27 May 2015

Membrane induced structure of novel human tachykinin Hemokinin-1 (hHK1)

Structural highlights

Function

References

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