4f40: Difference between revisions
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref> | [[http://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref> | ||
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== Publication Abstract from PubMed == | |||
The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 A for T. cruzi PGF, 1.25 A for T. cruzi PGF with NADP, 1.6 A for L. major PGF and 1.8 A for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (Rfree of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target. | |||
Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.,Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):609-14. doi:, 10.1107/S2053230X15006883. Epub 2015 Apr 21. PMID:25945716<ref>PMID:25945716</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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==See Also== | ==See Also== | ||
Revision as of 06:37, 3 June 2015
X-ray crystal structure of Apo prostaglandin f synthase from Leishmania major Friedlin
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