3b8z: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:3b8z.jpg|left|200px]] | [[Image:3b8z.jpg|left|200px]] | ||
'''High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)''' | {{Structure | ||
|PDB= 3b8z |SIZE=350|CAPTION= <scene name='initialview01'>3b8z</scene>, resolution 1.400Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=294:N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide'>294</scene> | |||
|ACTIVITY= | |||
|GENE= ADAMTS5, ADAMTS11, ADMP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
3B8Z is a [ | 3B8Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8Z OCA]. | ||
==Reference== | ==Reference== | ||
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:[http:// | High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17991750 17991750] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 24: | Line 33: | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:57:10 2008'' | ||
Revision as of 16:57, 20 March 2008
| |||||||||||||
| 3b8z, resolution 1.400Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | ZN, CA and 294 | ||||||||||||
| Gene: | ADAMTS5, ADAMTS11, ADMP2 (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)
Overview
Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.
About this Structure
3B8Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:17991750
Page seeded by OCA on Thu Mar 20 18:57:10 2008
