4pkm: Difference between revisions
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''' | ==Crystal Structure of Bacillus thuringiensis Cry51Aa1 Protoxin at 1.65 Angstroms Resolution== | ||
<StructureSection load='4pkm' size='340' side='right' caption='[[4pkm]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4pkm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PKM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PKM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pkm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pkm RCSB], [http://www.ebi.ac.uk/pdbsum/4pkm PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The structures of several Bacillus thuringiensis (Bt) insecticidal crystal proteins have been determined by crystallographic methods and a close relationship has been explicated between specific toxicities and conserved three-dimensional architectures. In this study, as a representative of the coleopteran- and hemipteran-specific Cry51A group, the complete structure of Cry51Aa1 protoxin has been determined by X-ray crystallography at 1.65 A resolution. This is the first report of a coleopteran-active Bt insecticidal toxin with high structural similarity to the aerolysin-type beta-pore forming toxins (beta-PFTs). Moreover, study of featured residues and structural elements reveal their possible roles in receptor binding and pore formation events. This study provides new insights into the action of aerolysin-type beta-PFTs from a structural perspective, and could be useful for the control of coleopteran and hemipteran insect pests in agricultures. | |||
Crystal structure of Cry51Aa1: A potential novel insecticidal aerolysin-type beta-pore-forming toxin from Bacillus thuringiensis.,Xu C, Chinte U, Chen L, Yao Q, Meng Y, Zhou D, Bi LJ, Rose J, Adang MJ, Wang BC, Yu Z, Sun M Biochem Biophys Res Commun. 2015 May 7. pii: S0006-291X(15)00758-5. doi:, 10.1016/j.bbrc.2015.04.068. PMID:25957471<ref>PMID:25957471</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bi, L J]] | |||
[[Category: Chen, L]] | |||
[[Category: Chinte, U]] | |||
[[Category: Li, L]] | |||
[[Category: Meng, Y]] | |||
[[Category: Rose, J]] | |||
[[Category: Sun, M]] | [[Category: Sun, M]] | ||
[[Category: | [[Category: Wang, B C]] | ||
[[Category: Xu, C]] | [[Category: Xu, C]] | ||
[[Category: Yao, Q]] | |||
[[Category: Yu, Z]] | [[Category: Yu, Z]] | ||
[[Category: Zhou, D]] | [[Category: Zhou, D]] | ||
[[Category: | [[Category: Bacterial toxin]] | ||
[[Category: Beetle]] | |||
[[Category: Beta-pore-forming toxin]] | |||
[[Category: Cry toxin]] | |||
[[Category: Insecticidal toxin]] | |||
[[Category: Pore-forming toxin]] | |||
[[Category: Pro-toxin]] | |||
[[Category: Toxin]] | |||
