4xos: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==ANP32A LRR domain==

~~The entry~~ 4xos is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4xos]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XOS FirstGlance]. <br>

~~Authors~~: ~~Zamora~~-~~Caballero~~, S., ~~Bravo~~, J.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xos RCSB], [http://www.ebi.ac.uk/pdbsum/4xos PDBsum]</span></td></tr>

~~Description~~: ~~ANP32A LRR domain~~

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[http://www.uniprot.org/uniprot/AN32A_HUMAN AN32A_HUMAN]] Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.<ref>PMID:15642345</ref> <ref>PMID:10400610</ref> <ref>PMID:11360199</ref> <ref>PMID:17557114</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bravo, J]]

[[Category: Zamora-Caballero, S]]

[[Category: ~~Bravo, J~~]]

[[Category: Antitumor protein]]

[[Category: Component of the set complex]]

[[Category: Leucine rich repeat tumor suppressor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==ANP32A LRR domain==
+<StructureSection load='4xos' size='340' side='right' caption='[[4xos]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
-The entry 4xos is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4xos]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XOS FirstGlance]. <br>
-Authors: Zamora-Caballero, S., Bravo, J.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xos RCSB], [http://www.ebi.ac.uk/pdbsum/4xos PDBsum]</span></td></tr>
-Description: ANP32A LRR domain
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/AN32A_HUMAN AN32A_HUMAN]] Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.<ref>PMID:15642345</ref> <ref>PMID:10400610</ref> <ref>PMID:11360199</ref> <ref>PMID:17557114</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bravo, J]]
 [[Category: Zamora-Caballero, S]]
-[[Category: Bravo, J]]
+[[Category: Antitumor protein]]
+[[Category: Component of the set complex]]
+[[Category: Leucine rich repeat tumor suppressor]]