4yxj: Difference between revisions
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''' | ==Structure of Thermotoga maritima DisA in complex with ApCpp== | ||
<StructureSection load='4yxj' size='340' side='right' caption='[[4yxj]], [[Resolution|resolution]] 2.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4yxj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXJ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c1y|3c1y]], [[3c1z|3c1z]], [[3c21|3c21]], [[3c23|3c23]], [[4yvz|4yvz]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [http://www.ebi.ac.uk/pdbsum/4yxj PDBsum]</span></td></tr> | ||
[[Category: Hopfner, K | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA]] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Diadenylate cyclase]] | |||
[[Category: Deimling, T]] | |||
[[Category: Hopfner, K P]] | |||
[[Category: Mueller, M]] | [[Category: Mueller, M]] | ||
[[Category: Witte, G]] | [[Category: Witte, G]] | ||
[[Category: | [[Category: C-di-amp synthesis]] | ||
[[Category: Dac domain]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Inhibitor]] | |||
[[Category: Pre-reaction state]] | |||
[[Category: Transferase]] | |||
