Intrinsically Disordered Protein: Difference between revisions
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== Practical Implications of IUPs == | == Practical Implications of IUPs == | ||
There is evidence that large intrinsically unstructured regions | There is evidence that large intrinsically unstructured regions interfere with crystallization<ref name="IDSG">PMID: 23232152</ref>. Oldfield ''et al.'', 2013<ref name="IDSG" />, concluded: | ||
<blockquote> | <blockquote> | ||
The limited amount of intrinsic disorder present as missing density regions agrees with the idea that intrinsically disordered regions, particularly long disordered regions, inhibits successful determination of crystal structures, and suggests that avoiding or tailoring disordered proteins may aid in the determination of crystal structures. | The limited amount of intrinsic disorder present as missing density regions agrees with the idea that intrinsically disordered regions, particularly long disordered regions, inhibits successful determination of crystal structures, and suggests that avoiding or tailoring disordered proteins may aid in the determination of crystal structures. | ||
