3bes: Difference between revisions

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[[Image:3bes.jpg|left|200px]]<br /><applet load="3bes" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:3bes.jpg|left|200px]]
caption="3bes, resolution 2.2&Aring;" />
 
'''Structure of a Poxvirus ifngbp/ifng Complex'''<br />
{{Structure
|PDB= 3bes |SIZE=350|CAPTION= <scene name='initialview01'>3bes</scene>, resolution 2.2&Aring;
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+R+267'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+R+268'>AC2</scene>, <scene name='pdbsite=AC3:Bma+Binding+Site+For+Residue+R+269'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+R+270'>AC4</scene>, <scene name='pdbsite=AC5:Po4+Binding+Site+For+Residue+R+1'>AC5</scene>, <scene name='pdbsite=AC6:Po4+Binding+Site+For+Residue+L+139'>AC6</scene> and <scene name='pdbsite=AC7:Po4+Binding+Site+For+Residue+R+3'>AC7</scene>
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
|ACTIVITY=
|GENE= IFNG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), C4R, IFNGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12643 Ectromelia virus])
}}
 
'''Structure of a Poxvirus ifngbp/ifng Complex'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
3BES is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Ectromelia_virus Ectromelia virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+R+267'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+R+268'>AC2</scene>, <scene name='pdbsite=AC3:Bma+Binding+Site+For+Residue+R+269'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+R+270'>AC4</scene>, <scene name='pdbsite=AC5:Po4+Binding+Site+For+Residue+R+1'>AC5</scene>, <scene name='pdbsite=AC6:Po4+Binding+Site+For+Residue+L+139'>AC6</scene> and <scene name='pdbsite=AC7:Po4+Binding+Site+For+Residue+R+3'>AC7</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BES OCA].  
3BES is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Ectromelia_virus Ectromelia virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BES OCA].  


==Reference==
==Reference==
Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein., Nuara AA, Walter LJ, Logsdon NJ, Yoon SI, Jones BC, Schriewer JM, Buller RM, Walter MR, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1861-6. Epub 2008 Feb 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18252829 18252829]
Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein., Nuara AA, Walter LJ, Logsdon NJ, Yoon SI, Jones BC, Schriewer JM, Buller RM, Walter MR, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1861-6. Epub 2008 Feb 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18252829 18252829]
[[Category: Ectromelia virus]]
[[Category: Ectromelia virus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: receptor]]
[[Category: receptor]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 27 07:48:47 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:58:25 2008''

Revision as of 16:58, 20 March 2008

File:3bes.jpg


Drag the structure with the mouse to rotate
3bes, resolution 2.2Å
Sites: AC1, AC2, AC3, AC4, AC5, AC6 and AC7
Ligands: NAG and PO4
Gene: IFNG (Homo sapiens), C4R, IFNGR (Ectromelia virus)
Coordinates: save as pdb, mmCIF, xml



Structure of a Poxvirus ifngbp/ifng Complex


Overview

Ectromelia virus (ECTV) encodes an IFN-gamma-binding protein (IFN-gammaBP(ECTV)) that disrupts IFN-gamma signaling and its ability to induce an antiviral state within cells. IFN-gammaBP(ECTV) is an important virulence factor that is highly conserved (>90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox. The 2.2-A crystal structure of the IFN-gammaBP(ECTV)/IFN-gamma complex reveals IFN-gammaBP(ECTV) consists of an IFN-gammaR1 ligand-binding domain and a 57-aa helix-turn-helix (HTH) motif that is structurally related to the transcription factor TFIIA. The HTH motif forms a tetramerization domain that results in an IFN-gammaBP(ECTV)/IFN-gamma complex containing four IFN-gammaBP(ECTV) chains and two IFN-gamma dimers. The structure, combined with biochemical and cell-based assays, demonstrates that IFN-gammaBP(ECTV) tetramers are required for efficient IFN-gamma antagonism.

About this Structure

3BES is a Protein complex structure of sequences from Ectromelia virus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein., Nuara AA, Walter LJ, Logsdon NJ, Yoon SI, Jones BC, Schriewer JM, Buller RM, Walter MR, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1861-6. Epub 2008 Feb 5. PMID:18252829

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