3bht: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:3bht.jpg|left|200px]]<br /><applet load="3bht" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:3bht.jpg|left|200px]]
caption="3bht, resolution 2.000&Aring;" />
 
'''Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3'''<br />
{{Structure
|PDB= 3bht |SIZE=350|CAPTION= <scene name='initialview01'>3bht</scene>, resolution 2.000&Aring;
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+B+1'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+D+2'>AC2</scene>, <scene name='pdbsite=AC3:Mfr+Binding+Site+For+Residue+A+299'>AC3</scene>, <scene name='pdbsite=AC4:Mfr+Binding+Site+For+Residue+C+299'>AC4</scene>, <scene name='pdbsite=AC5:Sgm+Binding+Site+For+Residue+B+4'>AC5</scene>, <scene name='pdbsite=AC6:Sgm+Binding+Site+For+Residue+B+5'>AC6</scene> and <scene name='pdbsite=AC7:Sgm+Binding+Site+For+Residue+D+3'>AC7</scene>
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MFR:'>MFR</scene> and <scene name='pdbligand=SGM:MONOTHIOGLYCEROL'>SGM</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22]
|GENE= CDK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CCNA2, CCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])
}}
 
'''Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
3BHT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=MFR:'>MFR</scene> and <scene name='pdbligand=SGM:'>SGM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] Known structural/functional Sites: <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+B+1'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+D+2'>AC2</scene>, <scene name='pdbsite=AC3:Mfr+Binding+Site+For+Residue+A+299'>AC3</scene>, <scene name='pdbsite=AC4:Mfr+Binding+Site+For+Residue+C+299'>AC4</scene>, <scene name='pdbsite=AC5:Sgm+Binding+Site+For+Residue+B+4'>AC5</scene>, <scene name='pdbsite=AC6:Sgm+Binding+Site+For+Residue+B+5'>AC6</scene> and <scene name='pdbsite=AC7:Sgm+Binding+Site+For+Residue+D+3'>AC7</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHT OCA].  
3BHT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHT OCA].  


==Reference==
==Reference==
Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases., Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schachtele C, Kubbutat MH, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, Notario V, Meijer L, Cancer Res. 2007 Sep 1;67(17):8325-34. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17804748 17804748]
Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases., Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schachtele C, Kubbutat MH, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, Notario V, Meijer L, Cancer Res. 2007 Sep 1;67(17):8325-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17804748 17804748]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
Line 43: Line 52:
[[Category: transferase]]
[[Category: transferase]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:05:46 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:58:58 2008''
Retrieved from "https://proteopedia.org/3bht"