4zke: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of the S. cerevisiae Ski7 GTPase-like domain, bound to GTP.==

~~The entry~~ 4zke is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4zke]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKE FirstGlance]. <br>

~~Authors~~: ~~Kowalinski~~, E., ~~Conti~~, E.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zke RCSB], [http://www.ebi.ac.uk/pdbsum/4zke PDBsum]</span></td></tr>

~~Description~~: ~~Crystal structure~~ of the S. ~~cerevisiae Ski7 GTPase~~-~~like domain, bound~~ to ~~GTP~~.

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[http://www.uniprot.org/uniprot/SKI7_YEAST SKI7_YEAST]] Represses the expression of non-poly(A) mRNAs like L-A or M viruses and is therefore involved in antiviral system. Mediates interactions via its N-terminus between the exosome and the SKI complex which operate in the 3'-to-5' mRNA-decay pathway. By interacting with NAM7, is also required for nonsense-mediated 3'-to-5' mRNA-decay (NMD). May recognize a stalled 80S ribosome at the 3'-end of a nonstop mRNA which leads to the recruitment of the exosome and SKI complexes to the mRNAs to be degraded.<ref>PMID:10074137</ref> <ref>PMID:11027292</ref> <ref>PMID:11514438</ref> <ref>PMID:11532933</ref> <ref>PMID:11910110</ref> <ref>PMID:12769863</ref> <ref>PMID:12881429</ref> <ref>PMID:14671320</ref> <ref>PMID:15933721</ref> <ref>PMID:6371496</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Conti, E]]

[[Category: Kowalinski, E]]

[[Category: ~~Conti, E~~]]

[[Category: Gtp binding protein]]

[[Category: Gtpase]]

[[Category: Hydrolase]]

[[Category: Ngd]]

[[Category: Ski]]

[[Category: Translation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of the S. cerevisiae Ski7 GTPase-like domain, bound to GTP.==
+<StructureSection load='4zke' size='340' side='right' caption='[[4zke]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-The entry 4zke is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4zke]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKE FirstGlance]. <br>
-Authors: Kowalinski, E., Conti, E.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zke RCSB], [http://www.ebi.ac.uk/pdbsum/4zke PDBsum]</span></td></tr>
-Description: Crystal structure of the S. cerevisiae Ski7 GTPase-like domain, bound to GTP.
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/SKI7_YEAST SKI7_YEAST]] Represses the expression of non-poly(A) mRNAs like L-A or M viruses and is therefore involved in antiviral system. Mediates interactions via its N-terminus between the exosome and the SKI complex which operate in the 3'-to-5' mRNA-decay pathway. By interacting with NAM7, is also required for nonsense-mediated 3'-to-5' mRNA-decay (NMD). May recognize a stalled 80S ribosome at the 3'-end of a nonstop mRNA which leads to the recruitment of the exosome and SKI complexes to the mRNAs to be degraded.<ref>PMID:10074137</ref> <ref>PMID:11027292</ref> <ref>PMID:11514438</ref> <ref>PMID:11532933</ref> <ref>PMID:11910110</ref> <ref>PMID:12769863</ref> <ref>PMID:12881429</ref> <ref>PMID:14671320</ref> <ref>PMID:15933721</ref> <ref>PMID:6371496</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Conti, E]]
 [[Category: Kowalinski, E]]
-[[Category: Conti, E]]
+[[Category: Gtp binding protein]]
+[[Category: Gtpase]]
+[[Category: Hydrolase]]
+[[Category: Ngd]]
+[[Category: Ski]]
+[[Category: Translation]]