3tss: Difference between revisions
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'''TOXIC SHOCK SYNDROME TOXIN-1 TETRAMUTANT, P2(1) CRYSTAL FORM''' | {{Structure | ||
|PDB= 3tss |SIZE=350|CAPTION= <scene name='initialview01'>3tss</scene>, resolution 1.9Å | |||
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|LIGAND= | |||
|ACTIVITY= | |||
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'''TOXIC SHOCK SYNDROME TOXIN-1 TETRAMUTANT, P2(1) CRYSTAL FORM''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
3TSS is a [ | 3TSS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSS OCA]. | ||
==Reference== | ==Reference== | ||
Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci. 1997 Jun;6(6):1220-7. PMID:[http:// | Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci. 1997 Jun;6(6):1220-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9194182 9194182] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
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[[Category: toxin]] | [[Category: toxin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:07:34 2008'' | ||
Revision as of 17:07, 20 March 2008
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TOXIC SHOCK SYNDROME TOXIN-1 TETRAMUTANT, P2(1) CRYSTAL FORM
Overview
The structure of toxic shock syndrome toxin-1 (TSST-1), the causative agent in toxic shock syndrome, has been determined in three crystal forms. The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between two symmetry-related molecules. Although not required for biological activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very low concentrations. In addition, the structure of the tetramutant TSST-1H [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify endotoxin shock, has been determined and refined in a fourth crystal form (R-factor = 0.173 to 1.9 A resolution).
About this Structure
3TSS is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci. 1997 Jun;6(6):1220-7. PMID:9194182
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