5c8h: Difference between revisions
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''' | ==Crystal structure of ORC2 C-terminal domain== | ||
<StructureSection load='5c8h' size='340' side='right' caption='[[5c8h]], [[Resolution|resolution]] 2.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5c8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C8H FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c8h RCSB], [http://www.ebi.ac.uk/pdbsum/5c8h PDBsum]</span></td></tr> | |||
</table> | |||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/ORC2_HUMAN ORC2_HUMAN]] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.<ref>PMID:22427655</ref> <ref>PMID:22935713</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Dong, A]] | [[Category: Dong, A]] | ||
[[Category: Edwards, A M]] | |||
[[Category: Loppnau, P]] | |||
[[Category: Min, J]] | [[Category: Min, J]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
[[Category: | [[Category: Xu, C]] | ||
[[Category: Dna replication]] | |||
[[Category: | [[Category: Replication]] | ||
[[Category: | [[Category: Sgc]] | ||
[[Category: | |||
Revision as of 14:57, 8 July 2015
Crystal structure of ORC2 C-terminal domain
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