Connexin: Difference between revisions

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GJB2 is a gene which encodes a member of the gap junction protein family. [http://www.uniprot.org/uniprot/P29033 Gap junctions] are specialized membrane regions containing hundreds of intercellular communication channels that allow the passage of molecules such as ions, metabolites, nucleotides and small peptides. The gap junctions were first characterized by [http://www.jic.ac.uk/microscopy/intro_EM.html electron microscopy] as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins also known as connexins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.<ref name='Structure'>pmid 19622859</ref>

[[image:co.jpg | thumb |~~350px~~ | center]] <ref>http://en.wikipedia.org/wiki/Connexin</ref>

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Revision as of 07:12, 9 July 2015 view source Safaa Salah Hussiesy (talk \| contribs) 177 edits No edit summary ← Older edit		Revision as of 07:13, 9 July 2015 view source Safaa Salah Hussiesy (talk \| contribs) 177 edits No edit summary Newer edit →
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	GJB2 is a gene which encodes a member of the gap junction protein family. [http://www.uniprot.org/uniprot/P29033 Gap junctions] are specialized membrane regions containing hundreds of intercellular communication channels that allow the passage of molecules such as ions, metabolites, nucleotides and small peptides. The gap junctions were first characterized by [http://www.jic.ac.uk/microscopy/intro_EM.html electron microscopy] as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins also known as connexins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.<ref name='Structure'>pmid 19622859</ref>		GJB2 is a gene which encodes a member of the gap junction protein family. [http://www.uniprot.org/uniprot/P29033 Gap junctions] are specialized membrane regions containing hundreds of intercellular communication channels that allow the passage of molecules such as ions, metabolites, nucleotides and small peptides. The gap junctions were first characterized by [http://www.jic.ac.uk/microscopy/intro_EM.html electron microscopy] as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins also known as connexins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.<ref name='Structure'>pmid 19622859</ref>

	[[image:co.jpg \| thumb \|~~350px~~ \| center]] <ref>http://en.wikipedia.org/wiki/Connexin</ref>		[[image:co.jpg \| thumb \|450px \| center]] <ref>http://en.wikipedia.org/wiki/Connexin</ref>