452d: Difference between revisions

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[[Image:452d.gif|left|200px]]<br /><applet load="452d" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:452d.gif|left|200px]]
caption="452d, resolution 1.6&Aring;" />
 
'''ACRIDINE BINDING TO DNA'''<br />
{{Structure
|PDB= 452d |SIZE=350|CAPTION= <scene name='initialview01'>452d</scene>, resolution 1.6&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=9AD:9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE'>9AD</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
|ACTIVITY=
|GENE=
}}
 
'''ACRIDINE BINDING TO DNA'''
 


==About this Structure==
==About this Structure==
452D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=9AD:'>9AD</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=452D OCA].  
452D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=452D OCA].  


==Reference==
==Reference==
Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution., Todd AK, Adams A, Thorpe JH, Denny WA, Wakelin LP, Cardin CJ, J Med Chem. 1999 Feb 25;42(4):536-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10052960 10052960]
Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution., Todd AK, Adams A, Thorpe JH, Denny WA, Wakelin LP, Cardin CJ, J Med Chem. 1999 Feb 25;42(4):536-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10052960 10052960]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Cardin, C J.]]
[[Category: Cardin, C J.]]
Line 17: Line 26:
[[Category: intercalation]]
[[Category: intercalation]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:12:30 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:08:25 2008''
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