4grt: Difference between revisions

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[[Image:4grt.jpg|left|200px]]<br /><applet load="4grt" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:4grt.jpg|left|200px]]
caption="4grt, resolution 2.80&Aring;" />
 
'''HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME'''<br />
{{Structure
|PDB= 4grt |SIZE=350|CAPTION= <scene name='initialview01'>4grt</scene>, resolution 2.80&Aring;
|SITE= <scene name='pdbsite=S1:The+Active+Site+HIS+(HIS+467)+Is+From+The+Other+Subunit'>S1</scene> and <scene name='pdbsite=TS3:Trypanothione+Forms+A+Mixed+Disulfide+Between+Sg1+Ts3+17+...'>TS3</scene>
|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene> and <scene name='pdbligand=GCG:BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE'>GCG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferred_entry:_1.8.1.7 Transferred entry: 1.8.1.7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.4.2 1.6.4.2]
|GENE=
}}
 
'''HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
4GRT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FAD:'>FAD</scene> and <scene name='pdbligand=GCG:'>GCG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_1.8.1.7 Transferred entry: 1.8.1.7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.4.2 1.6.4.2] Known structural/functional Sites: <scene name='pdbsite=S1:The+Active+Site+HIS+(HIS+467)+Is+From+The+Other+Subunit'>S1</scene> and <scene name='pdbsite=TS3:Trypanothione+Forms+A+Mixed+Disulfide+Between+Sg1+Ts3+17+...'>TS3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRT OCA].  
4GRT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRT OCA].  


==Reference==
==Reference==
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity., Stoll VS, Simpson SJ, Krauth-Siegel RL, Walsh CT, Pai EF, Biochemistry. 1997 May 27;36(21):6437-47. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9174360 9174360]
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity., Stoll VS, Simpson SJ, Krauth-Siegel RL, Walsh CT, Pai EF, Biochemistry. 1997 May 27;36(21):6437-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9174360 9174360]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: oxidoreductase]]
[[Category: oxidoreductase]]


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