5a0o: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==adhiron raised against p300==

== Structural highlights ==

<table><tr><td colspan='2'>[[5a0o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A0O FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a0o RCSB], [http://www.ebi.ac.uk/pdbsum/5a0o PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

The HIF-1alpha/p300 protein-protein interaction plays a key role in tumor metabolism and thus represents a high value target for anticancer drug-development. Although several studies have identified inhibitor candidates using rationale design, more detailed understanding of the interaction and binding interface is necessary to inform development of superior inhibitors. In this work, we report a detailed biophysical analysis of the native interaction with both peptide and Adhiron phage display experiments to identify novel binding motifs and binding regions of the surface of p300 to inform future inhibitor design.

~~The entry 5a0o is ON HOLD until Paper Publication~~

Exploration of the HIF-1alpha/p300 interface using peptide and Adhiron phage display technologies.,Kyle HF, Wickson KF, Stott J, Burslem GM, Breeze AL, Tiede C, Tomlinson DC, Warriner SL, Nelson A, Wilson AJ, Edwards TA Mol Biosyst. 2015 Jul 2. PMID:26135796<ref>PMID:26135796</ref>

~~Authors: Kyle, H.F., Wickson, K.F., Stott, J., Burslem, G.M., Breeze, A.L., Tiede~~, C.~~, Tomlinson, D.C., Warriner,~~ S.~~L., Nelson, A., Wilson, A.J., Edwards, T.A~~.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description: adhiron raised against p300~~

== References ==

[[Category: ~~Unreleased Structures~~]]

[[Category: Burslem, G.M]]

__TOC__

[[Category: ~~Wickson~~, K.F]]

</StructureSection>

[[Category: ~~Tomlinson~~, ~~D.C~~]]

[[Category: Breeze, A L]]

[[Category: Burslem, G M]]

[[Category: Edwards, T A]]

[[Category: Kyle, H F]]

[[Category: Nelson, A]]

[[Category: Stott, J]]

~~[[Category: Breeze, A.L]]~~

~~[[Category: Nelson, A]]~~

~~[[Category: Warriner, S.L]]~~

~~[[Category: Edwards, T.A]]~~

[[Category: Tiede, C]]

[[Category: Wilson, A.J]]

[[Category: Tomlinson, D C]]

[[Category: ~~Kyle, H.F~~]]

[[Category: Warriner, S L]]

[[Category: Wickson, K F]]

[[Category: Wilson, A J]]

[[Category: Affimer]]

[[Category: De novo protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==adhiron raised against p300==
+<StructureSection load='5a0o' size='340' side='right' caption='[[5a0o]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5a0o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A0O FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a0o RCSB], [http://www.ebi.ac.uk/pdbsum/5a0o PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The HIF-1alpha/p300 protein-protein interaction plays a key role in tumor metabolism and thus represents a high value target for anticancer drug-development. Although several studies have identified inhibitor candidates using rationale design, more detailed understanding of the interaction and binding interface is necessary to inform development of superior inhibitors. In this work, we report a detailed biophysical analysis of the native interaction with both peptide and Adhiron phage display experiments to identify novel binding motifs and binding regions of the surface of p300 to inform future inhibitor design.
-The entry 5a0o is ON HOLD  until Paper Publication
+Exploration of the HIF-1alpha/p300 interface using peptide and Adhiron phage display technologies.,Kyle HF, Wickson KF, Stott J, Burslem GM, Breeze AL, Tiede C, Tomlinson DC, Warriner SL, Nelson A, Wilson AJ, Edwards TA Mol Biosyst. 2015 Jul 2. PMID:26135796<ref>PMID:26135796</ref>
-Authors: Kyle, H.F., Wickson, K.F., Stott, J., Burslem, G.M., Breeze, A.L., Tiede, C., Tomlinson, D.C., Warriner, S.L., Nelson, A., Wilson, A.J., Edwards, T.A.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: adhiron raised against p300
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Burslem, G.M]]
+__TOC__
-[[Category: Wickson, K.F]]
+</StructureSection>
-[[Category: Tomlinson, D.C]]
+[[Category: Breeze, A L]]
+[[Category: Burslem, G M]]
+[[Category: Edwards, T A]]
+[[Category: Kyle, H F]]
+[[Category: Nelson, A]]
 [[Category: Stott, J]]
-[[Category: Breeze, A.L]]
-[[Category: Nelson, A]]
-[[Category: Warriner, S.L]]
-[[Category: Edwards, T.A]]
 [[Category: Tiede, C]]
-[[Category: Wilson, A.J]]
+[[Category: Tomlinson, D C]]
-[[Category: Kyle, H.F]]
+[[Category: Warriner, S L]]
+[[Category: Wickson, K F]]
+[[Category: Wilson, A J]]
+[[Category: Affimer]]
+[[Category: De novo protein]]