4tln: Difference between revisions

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[[Image:4tln.jpg|left|200px]]<br /><applet load="4tln" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:4tln.jpg|left|200px]]
caption="4tln, resolution 2.3&Aring;" />
 
'''BINDING OF HYDROXAMIC ACID INHIBITORS TO CRYSTALLINE THERMOLYSIN SUGGESTS A PENTACOORDINATE ZINC INTERMEDIATE IN CATALYSIS'''<br />
{{Structure
|PDB= 4tln |SIZE=350|CAPTION= <scene name='initialview01'>4tln</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=LNO:L-LEUCYL-HYDROXYLAMINE'>LNO</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27]
|GENE=
}}
 
'''BINDING OF HYDROXAMIC ACID INHIBITORS TO CRYSTALLINE THERMOLYSIN SUGGESTS A PENTACOORDINATE ZINC INTERMEDIATE IN CATALYSIS'''
 


==About this Structure==
==About this Structure==
4TLN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=LNO:'>LNO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLN OCA].  
4TLN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TLN OCA].  


==Reference==
==Reference==
Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis., Holmes MA, Matthews BW, Biochemistry. 1981 Nov 24;20(24):6912-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7317361 7317361]
Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis., Holmes MA, Matthews BW, Biochemistry. 1981 Nov 24;20(24):6912-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7317361 7317361]
[[Category: Bacillus thermoproteolyticus]]
[[Category: Bacillus thermoproteolyticus]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 18: Line 27:
[[Category: hydrolase (metalloproteinase)]]
[[Category: hydrolase (metalloproteinase)]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:11:14 2008''
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