4znb: Difference between revisions

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[[Image:4znb.jpg|left|200px]]<br /><applet load="4znb" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:4znb.jpg|left|200px]]
caption="4znb, resolution 2.65&Aring;" />
 
'''METALLO-BETA-LACTAMASE (C181S MUTANT)'''<br />
{{Structure
|PDB= 4znb |SIZE=350|CAPTION= <scene name='initialview01'>4znb</scene>, resolution 2.65&Aring;
|SITE= <scene name='pdbsite=NAA:Deduced+From+The+Coordination.+Na+Was+Present+In+The+Cry+...'>NAA</scene>, <scene name='pdbsite=NAB:Deduced+From+The+Coordination.+Na+Was+Present+In+The+Cry+...'>NAB</scene>, <scene name='pdbsite=ZNA:Only+The+Zn1+Site+Of+Binuclear+Zn+Center+Is+Occupied'>ZNA</scene> and <scene name='pdbsite=ZNB:Only+The+Zn1+Site+Of+Binuclear+Zn+Center+Is+Occupied'>ZNB</scene>
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE= CCRA3 (WITHOUT SIGNAL SEQUENCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=817 Bacteroides fragilis])
}}
 
'''METALLO-BETA-LACTAMASE (C181S MUTANT)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
4ZNB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacteroides_fragilis Bacteroides fragilis] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Known structural/functional Sites: <scene name='pdbsite=NAA:Deduced+From+The+Coordination.+Na+Was+Present+In+The+Cry+...'>NAA</scene>, <scene name='pdbsite=NAB:Deduced+From+The+Coordination.+Na+Was+Present+In+The+Cry+...'>NAB</scene>, <scene name='pdbsite=ZNA:Only+The+Zn1+Site+Of+Binuclear+Zn+Center+Is+Occupied'>ZNA</scene> and <scene name='pdbsite=ZNB:Only+The+Zn1+Site+Of+Binuclear+Zn+Center+Is+Occupied'>ZNB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZNB OCA].  
4ZNB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteroides_fragilis Bacteroides fragilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZNB OCA].  


==Reference==
==Reference==
Structural consequences of the active site substitution Cys181 ==&gt; Ser in metallo-beta-lactamase from Bacteroides fragilis., Li Z, Rasmussen BA, Herzberg O, Protein Sci. 1999 Jan;8(1):249-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10210203 10210203]
Structural consequences of the active site substitution Cys181 ==&gt; Ser in metallo-beta-lactamase from Bacteroides fragilis., Li Z, Rasmussen BA, Herzberg O, Protein Sci. 1999 Jan;8(1):249-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10210203 10210203]
[[Category: Bacteroides fragilis]]
[[Category: Bacteroides fragilis]]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
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[[Category: metallo beta-lactamase]]
[[Category: metallo beta-lactamase]]


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