5rla: Difference between revisions

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[[Image:5rla.gif|left|200px]]<br /><applet load="5rla" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:5rla.gif|left|200px]]
caption="5rla, resolution 2.74&Aring;" />
 
'''ALTERING THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE DIMINISHES THERMOSTABILITY AND CATALYTIC FUNCTION'''<br />
{{Structure
|PDB= 5rla |SIZE=350|CAPTION= <scene name='initialview01'>5rla</scene>, resolution 2.74&Aring;
|SITE= <scene name='pdbsite=MNA:Bi-Mn+Nuclear+Binding+Site'>MNA</scene>, <scene name='pdbsite=MNB:Bi-Mn+Nuclear+Binding+Site'>MNB</scene> and <scene name='pdbsite=MNC:Bi-Mn+Nuclear+Binding+Site'>MNC</scene>
|LIGAND= <scene name='pdbligand=MN:MANGANESE (II) ION'>MN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1]
|GENE= PARGR-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
}}
 
'''ALTERING THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE DIMINISHES THERMOSTABILITY AND CATALYTIC FUNCTION'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
5RLA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=MN:'>MN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] Known structural/functional Sites: <scene name='pdbsite=MNA:Bi-Mn+Nuclear+Binding+Site'>MNA</scene>, <scene name='pdbsite=MNB:Bi-Mn+Nuclear+Binding+Site'>MNB</scene> and <scene name='pdbsite=MNC:Bi-Mn+Nuclear+Binding+Site'>MNC</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RLA OCA].  
5RLA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RLA OCA].  


==Reference==
==Reference==
Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function., Scolnick LR, Kanyo ZF, Cavalli RC, Ash DE, Christianson DW, Biochemistry. 1997 Aug 26;36(34):10558-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9265637 9265637]
Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function., Scolnick LR, Kanyo ZF, Cavalli RC, Ash DE, Christianson DW, Biochemistry. 1997 Aug 26;36(34):10558-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9265637 9265637]
[[Category: Arginase]]
[[Category: Arginase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: urea cycle]]
[[Category: urea cycle]]


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