9pai: Difference between revisions
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[[Image:9pai.gif|left|200px]] | [[Image:9pai.gif|left|200px]] | ||
'''CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1''' | {{Structure | ||
|PDB= 9pai |SIZE=350|CAPTION= <scene name='initialview01'>9pai</scene>, resolution 2.7Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
9PAI is a [ | 9PAI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PAI OCA]. | ||
==Reference== | ==Reference== | ||
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1., Aertgeerts K, De Bondt HL, De Ranter CJ, Declerck PJ, Nat Struct Biol. 1995 Oct;2(10):891-7. PMID:[http:// | Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1., Aertgeerts K, De Bondt HL, De Ranter CJ, Declerck PJ, Nat Struct Biol. 1995 Oct;2(10):891-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7552714 7552714] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: serpin]] | [[Category: serpin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:16:41 2008'' | ||
Revision as of 17:16, 20 March 2008
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| 9pai, resolution 2.7Å | |||||||||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1
Overview
Plasminogen activator inhibitor-1 (PAI-1) is unique among the serine proteinase inhibitors (serpins) in that it can adopt at least three different conformations (active, substrate and latent). We report the X-ray structure of a cleaved substrate variant of human PAI-1, which has a new beta-strand s4A formed by insertion of the amino-terminal portion of the reactive-site loop into beta-sheet A subsequent to cleavage. This is in contrast to the previous suggestion that the non-inhibitory function of substrate-type serpins is mainly due to an inability of the reactive-site loop to adopt this conformation. Comparison with the structure of latent PAI-1 provides insights into the molecular determinants responsible for the transition of the stressed active conformation to the thermostable latent conformation.
Disease
Known diseases associated with this structure: Hemorrhagic diathesis due to PAI1 deficiency OMIM:[173360], Thrombophilia due to excessive plasminogen activator inhibitor OMIM:[173360]
About this Structure
9PAI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1., Aertgeerts K, De Bondt HL, De Ranter CJ, Declerck PJ, Nat Struct Biol. 1995 Oct;2(10):891-7. PMID:7552714
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