Outer surface protein

Outer surface proteins (Osp) are produced by the bacteria Borrelia burgdorferi which causes Lyme disease. OspA and OspB are upregulated when the bacteria enter the tick. OspA contributes to the colonization of the gut by the bacteria. OspC is a major antigen on the surface of the Lyme disease spirochetes when it is being transmitted to humans. For more details see:
OspA -

• G09SecL04Tpc2
  
• G1SecL05
  
• OspA

OspB -

• Outer surface protein B (OspB) of the Lyme disease spirochete bacterium
  
• G15SecL05Tpc3
  
• G14secL04Tpc3
  

OspC -

• OspC and Binding
  
• SB2013 L08gr01
  
• G18secL03Tpc4.

OxpA, OspB and OspC -

• Highlighted Proteins of Lyme Disease
  

3D structures of Outer surface proteins (Updated on 12-August-2015)

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• OspA
  • 1osp, 1fj1 – OspA (mutant) + antibody – Borrelia burgdorferi
    
  • 2af5, 2fkg, 2fkj, 2hkd, 2oyb – OspA
    
  • 2g8c, 2i5z, 2ol6, 2ol7, 2ol8, 2oy1, 2i5v, 2oy5, 2oy7, 2oy8, 2pi3, 3aum, 3cka,
  • 3ckf, 3ckg, 3ec5, 3eex - OspA (mutant)
    
• OspB
  • 1p4p – OspB C terminal
    
  • 1rjl - OspB+ antibody
    
  • 2yn7 – OspB
    
• OspC
  • 1ggq, 1g5z – OspC
    
  • 1f1m – OspC (mutant)
• OspE
  • 2m4f – OspE – NMR
    
  • 4j38 – OspE + complement factor H
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky