4v59

Crystal structure of fatty acid synthase complexed with nadp+ from thermomyces lanuginosus at 3.1 angstrom resolution.

spinqualitylabelsall models 4v59, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4v59 is a 12 chain structure with sequence from Thermomyces lanuginosus. This structure supersedes and combines the now removed PDB entries 2uvb and 2uvc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FMN, NAP Resources: FirstGlance, OCA, RCSB, PDBsum Warning: this is a large structure, and loading might take a long time or not happen at all. Publication Abstract from PubMed We report crystal structures of the 2.6-megadalton alpha6beta6 heterododecameric fatty acid synthase from Thermomyces lanuginosus at 3.1 angstrom resolution. The alpha and beta polypeptide chains form the six catalytic domains required for fatty acid synthesis and numerous expansion segments responsible for extensive intersubunit connections. Detailed views of all active sites provide insights into substrate specificities and catalytic mechanisms and reveal their unique characteristics, which are due to the integration into the multienzyme. The mode of acyl carrier protein attachment in the reaction chamber, together with the spatial distribution of active sites, suggests that iterative substrate shuttling is achieved by a relatively restricted circular motion of the carrier domain in the multifunctional enzyme. Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.,Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N Science. 2007 Apr 13;316(5822):254-61. PMID:17431175 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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