2mjx: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 5: | Line 5: | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mjx RCSB], [http://www.ebi.ac.uk/pdbsum/2mjx PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mjx RCSB], [http://www.ebi.ac.uk/pdbsum/2mjx PDBsum]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Mutations in the genome are responsible for several fatal genetic disorders. The default DNA repair mechanism restores the malfunction of the gene caused by mutation to maintain functional regularity and sequential integrity of the cell. Here, we have elucidated the NMR structure and the dynamics of GC mismatched DNA (PDB code: 2MJX) and found that the mismatched DNA still retains the typical B-type helical form, but in the process introduces backbone distortion resulting from frame-shifted base pairs. | |||
Double GC:GC mismatch in dsDNA enhances local dynamics retaining the DNA footprint: a high-resolution NMR study.,Ghosh A, Kar RK, Krishnamoorthy J, Chatterjee S, Bhunia A ChemMedChem. 2014 Sep;9(9):2059-64. doi: 10.1002/cmdc.201402238. Epub 2014 Jul, 30. PMID:25080019<ref>PMID:25080019</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
