|
|
| Line 1: |
Line 1: |
| ==Structure of dUTPase from Arabidopsis thaliana==
| | #REDIRECT [[4ooq]] This PDB entry is obsolete and replaced by 4ooq |
| <StructureSection load='2p9o' size='340' side='right' caption='[[2p9o]], [[Resolution|resolution]] 2.00Å' scene=''>
| |
| == Structural highlights ==
| |
| <table><tr><td colspan='2'>[[2p9o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P9O FirstGlance]. <br>
| |
| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
| |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">T6H20.30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
| |
| <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
| |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p9o RCSB], [http://www.ebi.ac.uk/pdbsum/2p9o PDBsum]</span></td></tr>
| |
| </table>
| |
| == Function ==
| |
| [[http://www.uniprot.org/uniprot/Q9STG6_ARATH Q9STG6_ARATH]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP, preventing uracil incorporation into DNA.<ref>PMID:20227352</ref>
| |
| == Evolutionary Conservation ==
| |
| [[Image:Consurf_key_small.gif|200px|right]]
| |
| Check<jmol>
| |
| <jmolCheckbox>
| |
| <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/2p9o_consurf.spt"</scriptWhenChecked>
| |
| <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
| |
| <text>to colour the structure by Evolutionary Conservation</text>
| |
| </jmolCheckbox>
| |
| </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
| |
| <div style="clear:both"></div>
| |
| | |
| ==See Also==
| |
| *[[Deoxyuridine 5'-triphosphate nucleotidohydrolase|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
| |
| == References ==
| |
| <references/>
| |
| __TOC__
| |
| </StructureSection>
| |
| [[Category: Arabidopsis thaliana]]
| |
| [[Category: DUTP diphosphatase]]
| |
| [[Category: Bajaj, M]]
| |
| [[Category: Moriyama, H]]
| |
| [[Category: Dutpase]]
| |
| [[Category: Hydrolase]]
| |
| [[Category: Magnesium binding]]
| |
This PDB entry is obsolete and replaced by 4ooq
