5cmr: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
''' | ==Crystal Structure of Linker-Mediated Zn-bound Human H-Ferritin variant 122H-delta C-star== | ||
<StructureSection load='5cmr' size='340' side='right' caption='[[5cmr]], [[Resolution|resolution]] 3.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5cmr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CMR FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BYD:N,N-DIHYDROXYBENZENE-1,4-DICARBOXAMIDE'>BYD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cmq|5cmq]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cmr RCSB], [http://www.ebi.ac.uk/pdbsum/5cmr PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We describe here the construction of a three-dimensional, porous, crystalline framework formed by spherical protein nodes that assemble into a prescribed lattice arrangement through metal-organic linker-directed interactions. The octahedral iron storage en-zyme, ferritin, was engineered in its C3 symmetric pores with tripodal Zn coordination sites. Dynamic light scat-tering and crystallographic studies established that this Zn-ferritin construct could robustly self-assemble into the desired bcc-type crystals upon coordination of a ditopic linker bearing hydroxamic acid functional groups. This system represents the first example of a ternary protein-metal-organic crystalline framework whose formation is fully dependent on each of its three components. | |||
A Metal Organic Framework with Spherical Protein Nodes: Rational Chemical Design of 3D Protein Crystals.,Sontz PA, Bailey JB, Ahn S, Tezcan FA J Am Chem Soc. 2015 Aug 25. PMID:26305584<ref>PMID:26305584</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: | [[Category: Ferroxidase]] | ||
[[Category: Ahn, S]] | [[Category: Ahn, S]] | ||
[[Category: Bailey, J B]] | |||
[[Category: Sontz, P A]] | |||
[[Category: Tezcan, F A]] | |||
[[Category: Metal binding]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Protein engineering]] | |||
[[Category: Supramolecular assembly]] | |||
Revision as of 11:16, 9 September 2015
Crystal Structure of Linker-Mediated Zn-bound Human H-Ferritin variant 122H-delta C-star
| ||||||||||||
