2n2f: Difference between revisions
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''' | ==Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor== | ||
<StructureSection load='2n2f' size='340' side='right' caption='[[2n2f]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N2F FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [http://www.ebi.ac.uk/pdbsum/2n2f PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[Category: | [[http://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Spinocerebellar ataxia type 23. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Connor, C O]] | |||
[[Category: Czaplicki, G]] | |||
[[Category: Didenko, T]] | |||
[[Category: Doncescu, N]] | [[Category: Doncescu, N]] | ||
[[Category: Milon, A]] | [[Category: Milon, A]] | ||
[[Category: | [[Category: Roth, B L]] | ||
[[Category: Stevens, R C]] | |||
[[Category: White, K]] | |||
[[Category: Wuthrich, K]] | [[Category: Wuthrich, K]] | ||
[[Category: | [[Category: Gpcr]] | ||
[[Category: | [[Category: Hormone receptor]] | ||
Revision as of 11:16, 9 September 2015
Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor
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