2jbr: Difference between revisions
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<StructureSection load='2jbr' size='340' side='right' caption='[[2jbr]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2jbr' size='340' side='right' caption='[[2jbr]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jbr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2jbr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciba Aciba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JBR FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jbr RCSB], [http://www.ebi.ac.uk/pdbsum/2jbr PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbr OCA], [http://pdbe.org/2jbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jbr RCSB], [http://www.ebi.ac.uk/pdbsum/2jbr PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/HPAH_ACIBA HPAH_ACIBA]] Oxygenase component of a two-component system that utilizes reduced FMN (FMNH2) supplied by the reductase component to catalyze the hydroxylation of 4-hydroxyphenylacetic acid, leading to the production of 3,4-dihydroxyphenylacetate (3,4-DHPA). Also utilizes other reduced flavins such as FADH2 and reduced riboflavin to a lesser extent. Only the compounds with a hydroxyl group in the para (p-) position can be hydroxylated. May also oxidize phenol to catechol, and hydroxylate other phenol derivatives.<ref>PMID:11683878</ref> <ref>PMID:15451173</ref> <ref>PMID:16042421</ref> <ref>PMID:16627482</ref> <ref>PMID:17595116</ref> <ref>PMID:21030590</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2jbr" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Aciba]] | ||
[[Category: Alfieri, A]] | [[Category: Alfieri, A]] | ||
[[Category: Mattevi, A]] | [[Category: Mattevi, A]] | ||
[[Category: Flavoenzyme hydroxylase]] | [[Category: Flavoenzyme hydroxylase]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
