1kmp

Crystal structure of the Outer Membrane Transporter FecA Complexed with Ferric Citrate

spinqualitylabelsall models 1kmp, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1kmp is a 1 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CIT, FE, LDA NonStd Res: MSE Related: 1kmo Gene: fecA (ECOLI) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum Function [FECA_ECOLI] FecA is the outer membrane receptor protein in the Fe(3+) dicitrate transport system. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Siderophore-mediated acquisition systems facilitate iron uptake. We present the crystallographic structure of the integral outer membrane receptor FecA from Escherichia coli with and without ferric citrate at 2.5 and 2.0 angstrom resolution. FecA is composed of three distinct domains: the barrel, plug, and NH2-terminal extension. Binding of ferric citrate triggers a conformational change of the extracellular loops that close the external pocket of FecA. Ligand-induced allosteric transitions are propagated through the outer membrane by the plug domain, signaling the occupancy of the receptor in the periplasm. These data establish the structural basis of gating for receptors dependent on the cytoplasmic membrane protein TonB. By compiling available data for this family of receptors, we propose a mechanism for the energy-dependent transport of siderophores. Structural basis of gating by the outer membrane transporter FecA.,Ferguson AD, Chakraborty R, Smith BS, Esser L, van der Helm D, Deisenhofer J Science. 2002 Mar 1;295(5560):1715-9. PMID:11872840 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA