1s8n: Difference between revisions
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|PDB= 1s8n |SIZE=350|CAPTION= <scene name='initialview01'>1s8n</scene>, resolution 1.482Å | |PDB= 1s8n |SIZE=350|CAPTION= <scene name='initialview01'>1s8n</scene>, resolution 1.482Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=AZI:AZIDE ION'>AZI</scene> | |LIGAND= <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= rv1626 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 Mycobacterium tuberculosis H37Rv]) | |GENE= rv1626 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 Mycobacterium tuberculosis H37Rv]) | ||
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam03861 ANTAR], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00156 REC], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3707 AmiR]</span> | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s8n OCA], [http://www.ebi.ac.uk/pdbsum/1s8n PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1s8n RCSB]</span> | |||
}} | }} | ||
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[[Category: TBSGC, TB Structural Genomics Consortium.]] | [[Category: TBSGC, TB Structural Genomics Consortium.]] | ||
[[Category: Tucker, P A.]] | [[Category: Tucker, P A.]] | ||
[[Category: protein structure initiative]] | [[Category: protein structure initiative]] | ||
[[Category: psi]] | [[Category: psi]] | ||
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[[Category: two component system]] | [[Category: two component system]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:04:26 2008'' | ||
Revision as of 04:04, 26 March 2008
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| 1s8n, resolution 1.482Å | |||||||||||||
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| Ligands: | AZI | ||||||||||||
| Gene: | rv1626 (Mycobacterium tuberculosis H37Rv) | ||||||||||||
| Domains: | ANTAR, REC, AmiR | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of Rv1626 from Mycobacterium tuberculosis
Overview
We describe the crystal structure of Rv1626 from Mycobacterium tuberculosis at 1.48 A resolution and the corresponding solution structure determined from small angle X-ray scattering. The N-terminal domain shows structural homology to the receiver domains found in bacterial two-component systems. The C-terminal domain has high structural homology to a recently discovered RNA binding domain involved in transcriptional antitermination. The molecule in solution was found to be monomeric as it is in the crystal, but in solution it undergoes a conformational change that is triggered by changes in ionic strength. This is the first structure that links the phosphorylation cascade of the two-component systems with the antitermination event in the transcriptional machinery. Rv1626 belongs to a family of proteins, which we propose calling phosphorylation-dependent transcriptional antitermination regulators, so far only found in bacteria, and includes NasT, a protein from the assimilatory nitrate/nitrite reductase operon of Azetobacter vinelandii.
About this Structure
1S8N is a Single protein structure of sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.
Reference
The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:15341725
Page seeded by OCA on Wed Mar 26 06:04:26 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Mycobacterium tuberculosis h37rv
- Single protein
- Feng, V.
- Morth, J P.
- Perry, L J.
- Svergun, D I.
- TBSGC, TB Structural Genomics Consortium.
- Tucker, P A.
- Protein structure initiative
- Psi
- Rv1626
- Structural genomic
- Tb structural genomics consortium
- Tbsgc
- Transcriptional antiterminator
- Two component system
