4yfz: Difference between revisions
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''' | ==Structural basis of glycan recognition in neonate-specific rotaviruses== | ||
<StructureSection load='4yfz' size='340' side='right' caption='[[4yfz]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4yfz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YFZ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yfw|4yfw]], [[4ye2|4ye2]], [[4yg0|4yg0]], [[4yg3|4yg3]], [[4yg6|4yg6]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yfz OCA], [http://pdbe.org/4yfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yfz RCSB], [http://www.ebi.ac.uk/pdbsum/4yfz PDBsum]</span></td></tr> | |||
[[ | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/B6RGK2_9REOV B6RGK2_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment (By similarity).[SAAS:SAAS00209906] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (By similarity).[SAAS:SAAS00209911] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hu, L]] | [[Category: Hu, L]] | ||
[[Category: Prasad, B | [[Category: Prasad, B V.V]] | ||
[[Category: Glycan]] | |||
[[Category: Rotavirus]] | |||
[[Category: Structural biology]] | |||
[[Category: Viral protein]] | |||
Revision as of 14:41, 30 September 2015
Structural basis of glycan recognition in neonate-specific rotaviruses
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