4yg3: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structural basis of glycan recognition in neonate-specific rotaviruses==

~~The entry~~ 4yg3 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4yg3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YG3 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YG3 FirstGlance].

~~Authors~~: Hu, L., ~~Prasad~~, B.V.V.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

~~Description: Structural basis of glycan recognition in neonate-specific rotaviruses~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yg3 OCA], [http://pdbe.org/4yg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4yg3 PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/VP4_ROTBB VP4_ROTBB]] Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. According to the considered strain, VP4 seems to essentially target sialic acid and/or the integrin heterodimer ITGA2/ITGB1 (By similarity). Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment (By similarity). VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (By similarity).

__TOC__

</StructureSection>

[[Category: Hu, L]]

[[Category: Prasad, B.V.V]]

[[Category: Prasad, B V.V]]

[[Category: Glycan]]

[[Category: Rotavirus]]

[[Category: Structural biology]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structural basis of glycan recognition in neonate-specific rotaviruses==
+<StructureSection load='4yg3' size='340' side='right' caption='[[4yg3]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
-The entry 4yg3 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4yg3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YG3 FirstGlance]. <br>
-Authors: Hu, L., Prasad, B.V.V.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yfw|4yfw]], [[4ye2|4ye2]], [[4yez|4yez]], [[4yg0|4yg0]], [[4yg6|4yg6]]</td></tr>
-Description: Structural basis of glycan recognition in neonate-specific rotaviruses
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yg3 OCA], [http://pdbe.org/4yg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yg3 RCSB], [http://www.ebi.ac.uk/pdbsum/4yg3 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/VP4_ROTBB VP4_ROTBB]] Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. According to the considered strain, VP4 seems to essentially target sialic acid and/or the integrin heterodimer ITGA2/ITGB1 (By similarity).  Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment (By similarity).  VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (By similarity).
+__TOC__
+</StructureSection>
 [[Category: Hu, L]]
-[[Category: Prasad, B.V.V]]
+[[Category: Prasad, B V.V]]
+[[Category: Glycan]]
+[[Category: Rotavirus]]
+[[Category: Structural biology]]
+[[Category: Viral protein]]