4zgp: Difference between revisions

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'''Unreleased structure'''
==Structure of Cdc123 from Schizosaccharomyces pombe==
<StructureSection load='4zgp' size='340' side='right' caption='[[4zgp]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4zgp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZGP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zgo|4zgo]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgp OCA], [http://pdbe.org/4zgp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zgp RCSB], [http://www.ebi.ac.uk/pdbsum/4zgp PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CD123_SCHPO CD123_SCHPO]] Regulates the cell cycle in a nutrient dependent manner.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Eukaryotic initiation factor 2 (eIF2), a heterotrimeric guanosine triphosphatase, has a central role in protein biosynthesis by supplying methionylated initiator tRNA to the ribosomal translation initiation complex and by serving as a target for translational control in response to stress. Recent work identified a novel step indispensable for eIF2 function: assembly of eIF2 from its three subunits by the cell proliferation protein Cdc123. We report the first crystal structure of a Cdc123 representative, that from Schizosaccharomyces pombe, both isolated and bound to domain III of Saccharomyces cerevisiae eIF2gamma. The structures show that Cdc123 resembles enzymes of the ATP-grasp family. Indeed, Cdc123 binds ATP-Mg(2+), and conserved residues contacting ATP-Mg(2+) are essential for Cdc123 to support eIF2 assembly and cell viability. A docking of eIF2alphagamma onto Cdc123, combined with genetic and biochemical experiments, allows us to propose a model explaining how Cdc123 participates in the biogenesis of eIF2 through facilitating assembly of eIF2gamma to eIF2alpha.


The entry 4zgp is ON HOLD  until Paper Publication
Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features.,Panvert M, Dubiez E, Arnold L, Perez J, Mechulam Y, Seufert W, Schmitt E Structure. 2015 Sep 1;23(9):1596-608. doi: 10.1016/j.str.2015.06.014. Epub 2015, Jul 23. PMID:26211610<ref>PMID:26211610</ref>


Authors: Panvert, M., Dubiez, E., Arnold, L., Perez, J., Seufert, W., Mechulam, Y., Schmitt, E.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description:  
<div class="pdbe-citations 4zgp" style="background-color:#fffaf0;"></div>
[[Category: Unreleased Structures]]
== References ==
[[Category: Schmitt, E]]
<references/>
[[Category: Perez, J]]
__TOC__
</StructureSection>
[[Category: Arnold, L]]
[[Category: Dubiez, E]]
[[Category: Mechulam, Y]]
[[Category: Mechulam, Y]]
[[Category: Dubiez, E]]
[[Category: Panvert, M]]
[[Category: Panvert, M]]
[[Category: Arnold, L]]
[[Category: Perez, J]]
[[Category: Schmitt, E]]
[[Category: Seufert, W]]
[[Category: Seufert, W]]
[[Category: Atp-grap fold]]
[[Category: Cell cycle]]
[[Category: Eif2]]
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