4pfd: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of M. tuberculosis in complex with a cBT - non-covalent adduct==

~~The entry~~ 4pfd is ~~ON HOLD until Oct 16 2016~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4pfd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFD OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PFD FirstGlance].

~~Authors~~: ~~Neres~~, J., ~~Panda~~, M.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=2R2:[4-(2-METHOXYETHYL)PIPERAZIN-1-YL][6-METHYL-7-NITRO-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-YL]METHANONE'>2R2</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4p8h|4p8h]], [[4pfa|4pfa]]</td></tr>

~~Description~~: ~~Crystal structure of M~~. ~~tuberculosis~~ in ~~complex with~~ a ~~cBT~~ -~~non~~-~~covalent adduct~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfd OCA], [http://pdbe.org/4pfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pfd RCSB], [http://www.ebi.ac.uk/pdbsum/4pfd PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU]] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Cole, S]]

[[Category: Neres, J]]

[[Category: Panda, M]]

[[Category: ~~Neres, J~~]]

[[Category: Covalent]]

[[Category: Dpre1]]

[[Category: Inhibitor]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of M. tuberculosis in complex with a cBT - non-covalent adduct==
+<StructureSection load='4pfd' size='340' side='right' caption='[[4pfd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-The entry 4pfd is ON HOLD  until Oct 16 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4pfd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PFD FirstGlance]. <br>
-Authors: Neres, J., Panda, M.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2R2:[4-(2-METHOXYETHYL)PIPERAZIN-1-YL][6-METHYL-7-NITRO-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-YL]METHANONE'>2R2</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p8h|4p8h]], [[4pfa|4pfa]]</td></tr>
-Description: Crystal structure of M. tuberculosis in complex with a cBT -non-covalent adduct
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfd OCA], [http://pdbe.org/4pfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pfd RCSB], [http://www.ebi.ac.uk/pdbsum/4pfd PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU]] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cole, S]]
+[[Category: Neres, J]]
 [[Category: Panda, M]]
-[[Category: Neres, J]]
+[[Category: Covalent]]
+[[Category: Dpre1]]
+[[Category: Inhibitor]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]