5bmu: Difference between revisions
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''' | ==The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S== | ||
<StructureSection load='5bmu' size='340' side='right' caption='[[5bmu]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5bmu]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BMU FirstGlance]. <br> | |||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate--tRNA_ligase Glutamate--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.17 6.1.1.17] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bmu OCA], [http://pdbe.org/5bmu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bmu RCSB], [http://www.ebi.ac.uk/pdbsum/5bmu PDBsum]</span></td></tr> | |||
</table> | |||
[[Category: | == Function == | ||
[[Category: Kang, B | [[http://www.uniprot.org/uniprot/MCA3_HUMAN MCA3_HUMAN]] Positive modulator of ATM response to DNA damage. [[http://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN]] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Glutamate--tRNA ligase]] | |||
[[Category: Cho, H J]] | |||
[[Category: Kang, B S]] | |||
[[Category: Aimp3]] | |||
[[Category: Epr]] | |||
[[Category: Gst-like domain]] | |||
[[Category: Translation-ligase complex]] | |||
Revision as of 05:33, 22 October 2015
The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S
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