Agrin: Difference between revisions
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{{STRUCTURE_3i70| PDB=3i70 | SIZE=400| SCENE=Agrin/Cv/1 |right|CAPTION=Chicken agrin, [[3i70]] }} | {{STRUCTURE_3i70| PDB=3i70 | SIZE=400| SCENE=Agrin/Cv/1 |right|CAPTION=Chicken agrin, [[3i70]] }} | ||
[[Agrin]] (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors. | == Function == | ||
[[Agrin]] (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors. | |||
== Disease == | |||
Agr is overexpressed in brains of Alzheimer Disease patients. Agr is associated with myasthenic syndrome. | |||
== Structural highlights == | |||
Agr N-terminal domain binds laminin. The C-terminal of Agr has 3 laminin-like globular domains (LMB) G1-G3 and 4 epidermal growth factor-like domains. Agr binds heparan sulfate post-translationally. Other Agr domains are: Kazal type serine protease inhibitor. | |||
== 3D Structures of Agrin == | == 3D Structures of Agrin == | ||
