Anthrax edema factor: Difference between revisions
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to a Jmol applet. Check out the other buttons as well! | to a Jmol applet. Check out the other buttons as well! | ||
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'''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. | |||
== Function == | |||
'''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The full anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. The binding of calmodulin to EF changes it from its non-active form to the active one. | |||
== Disease == | |||
The anthrax disease is caused by the invasion of cells by the bacteria followed by increasing the cellular level of cAMP thus upsetting water homeostasis and causing disruption of signaling pathways. | |||
==3D structures of anthrax edema factor== | ==3D structures of anthrax edema factor== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1lvc]] – EF adenylate cyclase domain + calmodulin + anthraniloyl-deoxy-ATP<br /> | [[1lvc]] – EF adenylate cyclase domain C terminal + calmodulin + anthraniloyl-deoxy-ATP<br /> | ||
[[1pk0]] - EF adenylate cyclase domain + calmodulin + phosphonylmethoxyethyl-ADP<br /> | [[1pk0]] - EF adenylate cyclase domain C terminal + calmodulin + phosphonylmethoxyethyl-ADP<br /> | ||
[[1s26]] - EF adenylate cyclase domain + calmodulin + methylene-ATP<br /> | [[1s26]] - EF adenylate cyclase domain C terminal + calmodulin + methylene-ATP<br /> | ||
[[1sk6]] - EF adenylate cyclase domain + calmodulin + pyrophosphate + cAMP<br /> | [[1sk6]] - EF adenylate cyclase domain C terminal + calmodulin + pyrophosphate + cAMP<br /> | ||
[[1xfu]] - EF | [[1xfu]] - EF (mutant) + calmodulin<br /> | ||
[[1xfv]] - EF | [[1xfv]] - EF + calmodulin + deoxy-ATP<br /> | ||
[[1xfw]] - EF | [[1xfw]] - EF + calmodulin + cAMP<br /> | ||
[[1xfx]], [[1xfy]], [[1xfz]] - EF | [[1xfx]], [[1xfy]], [[1xfz]] - EF + calmodulin | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
