Anti-silencing factor: Difference between revisions
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<StructureSection load='1roc' size='400' side='right' caption='Structure of yeast anti-silencing factor complex with Br- ions (PDB entry [[1roc]])' scene=''> | <StructureSection load='1roc' size='400' side='right' caption='Structure of yeast anti-silencing factor complex with Br- ions (PDB entry [[1roc]])' scene=''> | ||
== Function == | |||
'''Anti-silencing factor''' (ASF) or '''histone chaperone''' assits in chromatin assembly and remodeling during replication, transcription activation and gene silencing. ASF cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with histone regulatory homolog A (HIRA) to promote replication-independent assembly. | '''Anti-silencing factor''' (ASF) or '''histone chaperone''' assits in chromatin assembly and remodeling during replication, transcription activation and gene silencing. ASF cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with histone regulatory homolog A (HIRA) to promote replication-independent assembly. | ||
== Structural highlights == | |||
ASF has an 80 residue segment which binds RNA at the N-terminal and a C-terminal which is composed of 80% Ser and Arg. | |||
==3D structures of anti-silencing factor== | ==3D structures of anti-silencing factor== | ||
