Azurin

spinqualitylabelsall models Structure of azurin containing Cu+2 ion (PDB code 1joi). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Azurin (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center. Relevance AZ was found to be a novel anticancer agent. Following the entry of the P. aeruginosa bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells.

Structural highlights

AZ active Cu binding site is shown here.

3D structures of cAMP-dependent protein kinase

Updated on 08-November-2015

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• Azurin
  • 1e65 – PaAZ – Pseudomonas aeruginosa
    
• Cu+2 containing azurin
  • 1azu, 1azr, 4azu, 5azu, 1azn, 1cc3, 1e5y, 1e5z, 1jze, 2ft6, 2ft7, 2ft8, 2fta, 3fs9, 3fsa, 3fsv, 3fsw, 3fsz, 3ft0 – PaAZ
    
  • 3fq2, 4hip, 4qkt – PaAZ (mutant)
    
  • 1cuo, 1uat – AZ – Methylomonas
    
  • 1joi – PfAZ – Pseudomonas fluorrescens
    
  • 1nwo – PpAZ – Pseudomonas putida
    
  • 1nwp – PpAZ + Zn+2
    
  • 2aza, 1azb, 1azc, 1rkr – AxAZ – Achromobacter xylosoxidans
    
  • 1dyz, 1dz0, 2ccw – AZ II – Alcaligenes xylosoxidans
    
  • 2azu, 3azu, 1ils, 1ilu, 2tsa, 2tsb, 1etj, 1ag0, 1ezl, 1jvo, 1gr7, 1xb3, 1xb6, 1xb8, 2ghz, 2hx7, 2oj1, 3in0, 3fpy, 3fq1, [3fq2]], 3fqy, 3in2, 3jt2, 3jtb, 3np3, 3np4, 3oqr, 3n2j, 3u25, 4hhw, 4mfh, 4ko5, 4ko6, 4ko7, 4ko9, 4kob, 4koc, 4bww – PaAZ (mutant)
    
  • 1jvl, 2idf – PaAZ (mutant) + Ni+2
    
  • 1uri, 1a4a, 1a4b, 1a4c – AdAZ (mutant)
    
  • 2h3x, 2h47, 2iaa – AZ + aromatic amine dehydrogenase – Alcaligenes faecalis
    
• Cu+2 containing lanthanide-modified azurin
  • 1bex, 1jzi, 1jze, 1jzf, 1jzj, 1jzh – PaAZ
    
  • 2i7s, 2fnw, 2i7o, 3ibo, 4hhg, 4k9j – PaAZ (mutant)
    
• Cu+1 containing azurin
  • 1jzg – PaAZ
    
  • 1r1c, 2gi0, 1i53, 2hx8, 2hx9, 2hxa, 2xv0, 2xv2, 2xv3 – PaAZ (mutant)
    
• Other metals-containing azurin
  • 1aiz – AdAZ + Cd+2 – Achromobacter denitrificans
    
  • 1nzr – PaAZ (mutant) + Ni+2
    
  • 1vlx – PaAZ + Co+2
    
  • 1e67 – PaAZ + Zn+2
    
  • 2iwe – PaAZ (mutant) + Zn+2
    
  • 3ay2 – AZ (mutant) + Zn+2 – Neisseria Gonorhoeae
    
  • 3uge – PaAZ + Ag+1
    
  • 4hz1 – PaAZ + Fe+2
    
  • 4qlw – PaAZ (mutant) + Fe+2
    
  • 4jkn – PaAZ + Hg+2
    

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Michal Harel, Alexander Berchansky