Sandbox8999: Difference between revisions
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[[Link title]]== | [[Link title]]==Clathrin== | ||
{{STRUCTURE_3lvg| PDB=3lvg | SIZE=400| SCENE= |right|CAPTION=Bovine clathrin heavy (grey, green, pink) and light (yellow, magenta, cyan) chains, [[3lvg]] }} | |||
== History == | |||
The word clathrin originates from the Latin word clāthrāre, meaning “to provide with a lattice”. Clathrin is a protein involved in receptor-mediated endocytosis.1 It was not discovered until 1975 by Barbara Pearse, a British biological scientist. Clathrin is a protein resembling a triskelion shape and is composed of three heavy chains and three light chains which come together to form a polyhedral lattice similar to a cage. The three heavy chains resemble three legs protruding from a center point. Some of the major functions of clathrin include lysosomal targeting, receptor-mediated endocytosis, and organelle biogenesis from the trans-Golgi network.3 The polyhedral lattice shape of clathrin largely determines its functionality, in that there are many binding sites for proteins on the heavy chains of the lattice as well.'''<ref>'''Ungewickell, E., & Brandon, D. (1981). Assembly units of clathrin coats. "Nature, 289, 420-422". '''[http://dx.doi.org/10.1038/289420a0''' doi: 10.1038/289420a0''']</ref>''' | The word clathrin originates from the Latin word clāthrāre, meaning “to provide with a lattice”. Clathrin is a protein involved in receptor-mediated endocytosis.1 It was not discovered until 1975 by Barbara Pearse, a British biological scientist. Clathrin is a protein resembling a triskelion shape and is composed of three heavy chains and three light chains which come together to form a polyhedral lattice similar to a cage. The three heavy chains resemble three legs protruding from a center point. Some of the major functions of clathrin include lysosomal targeting, receptor-mediated endocytosis, and organelle biogenesis from the trans-Golgi network.3 The polyhedral lattice shape of clathrin largely determines its functionality, in that there are many binding sites for proteins on the heavy chains of the lattice as well.'''<ref>'''Ungewickell, E., & Brandon, D. (1981). Assembly units of clathrin coats. "Nature, 289, 420-422". '''[http://dx.doi.org/10.1038/289420a0''' doi: 10.1038/289420a0''']</ref>''' | ||
