Sandbox8999: Difference between revisions

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== Structure ==

An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain. This structure is often referred to as a triskelion shape.1 The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.1 The aforementioned zig-zags are what create the “leg” looking structure of the triskelion. 1 Part of the heavy chain is designated to bind to the light chains, of which there are two variations in mammals. The heavy chain and light chain bind through one long alpha helix towards the center of the protein. 1 [[Image:Clathrin-Cage.jpg]]

'''Individual Molecule'''

An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain. This structure is often referred to as a triskelion shape.1 The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.1 The aforementioned zig-zags are what create the “leg” looking structure of the triskelion. 1 Part of the heavy chain is designated to bind to the light chains, of which there are two variations in mammals. The heavy chain and light chain bind through one long alpha helix towards the center of the protein. 1

'''Lattice'''

Individual clathrin molecules can assemble into cage-like structures. When individual clathrin molecules come together, a lattice is formed where each lattice point is associated with the center of a triskelion (from the Greek word meaning “a three legged structure”)1

[[Image:Clathrin-Cage.jpg]]

== Function ==

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 == Structure ==
-An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain.  This structure is often referred to as a triskelion shape.1 The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.1  The aforementioned zig-zags are what create the “leg” looking structure of the triskelion. 1 Part of the heavy chain is designated to bind to the light chains, of which there are two variations in mammals.   The heavy chain and light chain bind through one long alpha helix towards the center of the protein. 1 [[Image:Clathrin-Cage.jpg]]
+'''Individual Molecule'''
+An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain.  This structure is often referred to as a triskelion shape.1 The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.1  The aforementioned zig-zags are what create the “leg” looking structure of the triskelion. 1 Part of the heavy chain is designated to bind to the light chains, of which there are two variations in mammals.   The heavy chain and light chain bind through one long alpha helix towards the center of the protein. 1
+'''Lattice'''
+Individual clathrin molecules can assemble into cage-like structures. When individual clathrin molecules come together, a lattice is formed where each lattice point is associated with the center of a triskelion (from the Greek word meaning “a three legged structure”)1
+ [[Image:Clathrin-Cage.jpg]]
 == Function ==