Sandbox8999: Difference between revisions

The '''noncanonical clathrin pathway''' refers to clathrin-actin assemblies, which form phagocytotic vesicles in response to invading bacterium.<ref name="harrison" /> Pathogen invasion into nonphagocytic cells result in the recruitment of clathrin.<ref name="harrison" /> These pathogens invade the cell through a process called the “zippering” mechanism, in which actin filaments are utilized to surround the pathogens with the host-cell membrane.<ref name="harrison" /> Actin recruitment requires the formation of clathrin patches and thus the clathrin-assembly forms.<ref name="harrison" /> Actin is not usually needed in classical endocytosis, but it is required when the size of the cargo in the forming vesicle is too large for the vesicle to close.<ref name="harrison" /> This association between actin and clathrin is unique to this pathway and distinguishes the noncanonical from the canonical pathway.<ref name="harrison" />

== Structural highlights ==