Sandbox8999: Difference between revisions

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===Lattice===

Individual clathrin molecules can assemble into cage-like structures. When individual clathrin molecules come together, a lattice is formed where each lattice point is associated with the center of a triskelion (from the Greek word meaning “a three legged structure”). <ref name="harrison" /> According to Crowther, R.A., clathrin vesicles are constructed from 12 pentagonal units plus a number of hexagonal units, with the number of hexagons increasing for larger clathrin coats<ref name="crowther">PMID: 7328122 </ref>. The term “cage” can be used to refer to empty shells composed only of clathrin where “coat” refers to clathrin plus associated proteins and vesicles. Clathrin lattices are formed under optimal conditions of physiological pH (6.0-6.5) and in the presence of Calcium or Magnesium ions. Various packing models have been investigated as to how the individual triskelion legs assemble into clathrin cages. As mentioned above, the center of the triskelion legs occurs at each vertex of the cage, meaning pentagons, heptagons, and hexagons can be formed. In the individual triskelion legs, the bend in the leg is 160 Angstroms from the vertex, giving rise to two models of packing: ~~Simple~~ side-by-side packing or a cross-over type of packing. Cross-over packing occurs when a hexamer of triskelions are formed with crossing over of the leg portions of the triskelions. Simple packing does not involve crossing over, but side by side packing of the leg portions of the triskelions.

Individual clathrin molecules can assemble into cage-like structures. When individual clathrin molecules come together, a lattice is formed where each lattice point is associated with the center of a triskelion (from the Greek word meaning “a three legged structure”). <ref name="harrison" /> According to Crowther, R.A., clathrin vesicles are constructed from 12 pentagonal units plus a number of hexagonal units, with the number of hexagons increasing for larger clathrin coats<ref name="crowther">PMID: 7328122 </ref>. The term “cage” can be used to refer to empty shells composed only of clathrin where “coat” refers to clathrin plus associated proteins and vesicles<ref name="crowther" />. Clathrin lattices are formed under optimal conditions of physiological pH (6.0-6.5) and in the presence of Calcium or Magnesium ions<ref name="crowther" />. Various packing models have been investigated as to how the individual triskelion legs assemble into clathrin cages<ref name="crowther" />. As mentioned above, the center of the triskelion legs occurs at each vertex of the cage, meaning pentagons, heptagons, and hexagons can be formed<ref name="crowther" />. In the individual triskelion legs, the bend in the leg is 160 Angstroms from the vertex, giving rise to two models of packing: simple side-by-side packing or a cross-over type of packing<ref name="crowther" />. Cross-over packing occurs when a hexamer of triskelions are formed with crossing over of the leg portions of the triskelions<ref name="crowther" />. Simple packing does not involve crossing over, but side by side packing of the leg portions of the triskelions<ref name="crowther" />.

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 ===Lattice===
-Individual clathrin molecules can assemble into cage-like structures. When individual clathrin molecules come together, a lattice is formed where each lattice point is associated with the center of a triskelion (from the Greek word meaning “a three legged structure”). <ref name="harrison" /> According to Crowther, R.A., clathrin vesicles are constructed from 12 pentagonal units plus a number of hexagonal units, with the number of hexagons increasing for larger clathrin coats<ref name="crowther">PMID: 7328122 </ref>. The term “cage” can be used to refer to empty shells composed only of clathrin where “coat” refers to clathrin plus associated proteins and vesicles. Clathrin lattices are formed under optimal conditions of physiological pH (6.0-6.5) and in the presence of Calcium or Magnesium ions. Various packing models have been investigated as to how the individual triskelion legs assemble into clathrin cages. As mentioned above, the center of the triskelion legs occurs at each vertex of the cage, meaning pentagons, heptagons, and hexagons can be formed. In the individual triskelion legs, the bend in the leg is 160 Angstroms from the vertex, giving rise to two models of packing: Simple side-by-side packing or a cross-over type of packing. Cross-over packing occurs when a hexamer of triskelions are formed with crossing over of the leg portions of the triskelions. Simple packing does not involve crossing over, but side by side packing of the leg portions of the triskelions.
+Individual clathrin molecules can assemble into cage-like structures. When individual clathrin molecules come together, a lattice is formed where each lattice point is associated with the center of a triskelion (from the Greek word meaning “a three legged structure”). <ref name="harrison" /> According to Crowther, R.A., clathrin vesicles are constructed from 12 pentagonal units plus a number of hexagonal units, with the number of hexagons increasing for larger clathrin coats<ref name="crowther">PMID: 7328122 </ref>. The term “cage” can be used to refer to empty shells composed only of clathrin where “coat” refers to clathrin plus associated proteins and vesicles<ref name="crowther" />. Clathrin lattices are formed under optimal conditions of physiological pH (6.0-6.5) and in the presence of Calcium or Magnesium ions<ref name="crowther" />. Various packing models have been investigated as to how the individual triskelion legs assemble into clathrin cages<ref name="crowther" />. As mentioned above, the center of the triskelion legs occurs at each vertex of the cage, meaning pentagons, heptagons, and hexagons can be formed<ref name="crowther" />. In the individual triskelion legs, the bend in the leg is 160 Angstroms from the vertex, giving rise to two models of packing: simple side-by-side packing or a cross-over type of packing<ref name="crowther" />. Cross-over packing occurs when a hexamer of triskelions are formed with crossing over of the leg portions of the triskelions<ref name="crowther" />. Simple packing does not involve crossing over, but side by side packing of the leg portions of the triskelions<ref name="crowther" />.
 == Function ==