Sandbox 7465: Difference between revisions
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<Structure load='4NB0' size='350' frame='true' align='right' caption='This is a crystal structure of FosB from ''Staphylococcus aureus'''This is a similar structure to DeltaFosB, although it retains 2 destabilizing elements which are spliced in the DeltaFosB variant.The DeltaFosB transcription factor should include 3 domains, a transactivating domain, a DNA binding domain, and a signal sensing domain. DeltaFosB includes is a basic motif, a Leucine zipper, and a bZIP domain scene='Insert optional scene name here' />== | <Structure load='4NB0' size='350' frame='true' align='right' caption='This is a crystal structure of FosB from ''Staphylococcus aureus'''This is a similar structure to DeltaFosB, although it retains 2 destabilizing elements which are spliced in the DeltaFosB variant.The DeltaFosB transcription factor should include 3 domains, a transactivating domain, a DNA binding domain, and a signal sensing domain. DeltaFosB includes is a basic motif, a Leucine zipper, and a bZIP domain scene='Insert optional scene name here' />==DeltaFosB | ||
FIGURE: | FIGURE: | ||
This is a crystal structure of FosB from ''Staphylococcus aureus''' This is a similar structure to DeltaFosB, although it retains 2 destabilizing elements which are spliced in the DeltaFosB variant.The DeltaFosB transcription factor should include 3 domains, a transactivating domain, a DNA binding domain, and a signal sensing domain. DeltaFosB includes is a basic motif, a Leucine zipper, and a bZIP domain scene | This is a crystal structure of FosB from ''Staphylococcus aureus''' This is a similar structure to DeltaFosB, although it retains 2 destabilizing elements which are spliced in the DeltaFosB variant.The DeltaFosB transcription factor should include 3 domains, a transactivating domain, a DNA binding domain, and a signal sensing domain. DeltaFosB includes is a basic motif, a Leucine zipper, and a bZIP domain scene | ||
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It has also been found that levels of DeltaFosB are higher when drugs are self-administered rather than experimentally injected. This implies that DeltaFosB levels may be affected by behavioral rather than purely physiological effects of the drug. | It has also been found that levels of DeltaFosB are higher when drugs are self-administered rather than experimentally injected. This implies that DeltaFosB levels may be affected by behavioral rather than purely physiological effects of the drug. | ||
This effect is underscored by a study which measured levels of DeltaFosB following a period of increased sexual activity (Pitchers et al., 2013). After a period of abstinence of 1, 7, or 28 days, levels of DeltaFosB in the Nucleus Accumbens were measured. As found in drug studies, DeltaFosB persisted in the NAc neurons of sexually active rats for at least 28 days after abstaining from the reward behavior. It can be concluded that there are similarities in the effects of both natural and drug rewards on the mesolimbic system. | This effect is underscored by a study which measured levels of DeltaFosB following a period of increased sexual activity (Pitchers et al., 2013). After a period of abstinence of 1, 7, or 28 days, levels of DeltaFosB in the Nucleus Accumbens were measured. As found in drug studies, DeltaFosB persisted in the NAc neurons of sexually active rats for at least 28 days after abstaining from the reward behavior. It can be concluded that there are similarities in the effects of both natural and drug rewards on the mesolimbic system. | ||
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<StructureSection load='1stp' size='340' side='right' caption='This is a crystal structure of FosB from ''Staphylococcus aureus'''This is a similar structure to DeltaFosB, although it retains 2 destabilizing elements which are spliced in the DeltaFosB variant.The DeltaFosB transcription factor should include 3 domains, a transactivating domain, a DNA binding domain, and a signal sensing domain. DeltaFosB includes is a basic motif, a Leucine zipper, and a bZIP domain scene=''> | |||
