Cellobiohydrolase

spinqualitylabelsall models Glycosylated cellobiohydrolase I catalytic domain complex with cellobiose and Cd+2 ions (yellow) (PDB code 3cel) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cellobiohydrolase (CBH) is a cellulase which degrades cellulose by hydrolysing the 1,4-β-D-glycosidic bonds. CBH is an exocellulase which cleaves two to four units from the ends of cellulose. There are two types of CBH. CBHI cleaves progressively from the reducing end while CBHII cleaves progressively from the nonreducing end of cellulose. Structural highlights The active site of CBH contains Glu-Asp-Glu (Gln-Asp-Glu in 3cel, cyan) and is situated at the bottom of a tunnel.

3D structures of cellobiohydrolase

Updated on 30-November-2015

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• Cellobiohydrolase I

• • 3cel – HjCBHI core – Hypocrea jecorina
    
  • 1cbh, 2cbh – HjCBHI C terminal – NMR
    
  • 1azh, 1az6, 1azj, 1azk - HjCBHI cellulose-binding domain (mutant) - NMR
    
  • 2cel, 4cel, 1egn, 1q2b - HjCBHI catalytic domain (mutant)
    
  • 1gpi - PcCBHI catalytic domain – Phanerochaete chrysosporium
    
  • 1q9h, 3pfj - TeCBHI catalytic domain – Talaromyces emersonii
    
  • 2y9l, 2y9n - CBHI catalytic domain – Hypocrea lixii
• Cellobiohydrolase I binary complex
  • 3cel - HjCBHI catalytic domain (mutant) + cellobiose
    
  • 5cel, 1q2e - HjCBHI catalytic domain (mutant) + cellotetraose
    
  • 6cel - HjCBHI catalytic domain (mutant) + cellopentaose
    
  • 7cel - HjCBHI catalytic domain (mutant) + glucose
    
  • 2v3i, 2v3r - HjCBHI catalytic domain + phenanthrenolol
    
  • 1dy4 - TrCBHI catalytic domain + propranolol – Trichoderma reesei
    
  • 1h46 - PcCBHI catalytic domain + propranolol
    
  • 1z3t - PcCBHI catalytic domain + cellobiose
    
  • 1z3v - PcCBHI catalytic domain + lactose
    
  • 1z3w - PcCBHI catalytic domain + cellobioimidazole
    
  • 3pfx - TeCBHI catalytic domain + cellobiose
    
  • 3pfz - TeCBHI catalytic domain + cellotetraose + cellobiose
    
  • 3pl3 - TeCBHI catalytic domain + cellopentaose
    
• Cellobiohydrolase II
  • 3cbh – HjCBHII core
    
  • 1cb2 – HjCBHII catalytic domain (mutant)
    
  • 1hgw, 1hgy, 1oc6 – HjCBHII catalytic domain (mutant)
• Cellobiohydrolase II binary complex
  • 1bvw - HiCBHII catalytic domain + mannose – Humicola insolens
    
  • 2bvw - HiCBHII catalytic domain + glucose + cellotetraose
    
  • 1gz1, 1oc5 - HiCBHII catalytic domain (mutant) + cellotetraose
    
  • 1oc7 - HiCBHII catalytic domain (mutant) + cellopentaose
    
  • 1ocj - HiCBHII catalytic domain + cellopentaose
    
  • 1ocb - HiCBHII catalytic domain + fluorescent substrate
    
  • 1ocn - HiCBHII catalytic domain (mutant) + isofagomine
    
  • 1qjw - TrCBHII catalytic domain (mutant) + cellotetraose
    
  • 1qk0 - TrCBHII catalytic domain + polysaccharide
    
  • 1qk2 - TrCBHII catalytic domain + cellotetraose
    
• Other cellobiohydrolases
  • 1l1y – CtCBH – Clostridium thermocellum
    
  • 1rq5 - CtCBH (mutant)
    
  • 1ut9 - CtCBH catalytic domain
    
  • 1sqj - GeCBH – Geotrichum
    
  • 3a64, 3vog - CcCBH catalytic domain - Coprinopsis cinerea
    
  • 3vof, 3voj - CcCBHI catalytic domain (mutant)
    
  • 4v1z – AfCBH 7A – Aspergillus fumigatus
    
• Other cellobiohydrolases binary complex
  • 1l2a - CtCBH + glucose
    
  • 2ebs – GeCBH (mutant) + heptasaccharide
    
  • 3a9b, 3voh - CcCBHI catalytic domain + cellobiose
    
  • 3abx, 3voi - CcCBHI catalytic domain + cellotriose
    
  • 4v20 - AfCBH 7A + disaccharide
    

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