4d4w: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Solution structure of human MBD1 CXXC1 domain==

~~The entry~~ 4d4w is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4d4w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4W FirstGlance]. <br>

~~Authors~~: ~~THOMSON~~, R., ~~SMITH~~, B.O.

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4w OCA], [http://pdbe.org/4d4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d4w RCSB], [http://www.ebi.ac.uk/pdbsum/4d4w PDBsum]</span></td></tr>

</table>

~~Description~~: ~~Solution structure~~ of ~~human MBD1 CXXC1 domain~~

== Function ==

[[Category: ~~Unreleased Structures~~]]

[[http://www.uniprot.org/uniprot/MBD1_HUMAN MBD1_HUMAN]] Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.<ref>PMID:9207790</ref> <ref>PMID:10454587</ref> <ref>PMID:9774669</ref> <ref>PMID:10648624</ref> <ref>PMID:12711603</ref> <ref>PMID:12665582</ref> <ref>PMID:12697822</ref> <ref>PMID:14610093</ref> <ref>PMID:15327775</ref> <ref>PMID:14555760</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Smith, B O]]

[[Category: Thomson, R]]

[[Category: ~~Smith, B.O~~]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Solution structure of human MBD1 CXXC1 domain==
+<StructureSection load='4d4w' size='340' side='right' caption='[[4d4w]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
-The entry 4d4w is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4d4w]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D4W FirstGlance]. <br>
-Authors: THOMSON, R., SMITH, B.O.
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d4w OCA], [http://pdbe.org/4d4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d4w RCSB], [http://www.ebi.ac.uk/pdbsum/4d4w PDBsum]</span></td></tr>
+</table>
-Description: Solution structure of human MBD1 CXXC1 domain
+== Function ==
-[[Category: Unreleased Structures]]
+[[http://www.uniprot.org/uniprot/MBD1_HUMAN MBD1_HUMAN]] Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.<ref>PMID:9207790</ref> <ref>PMID:10454587</ref> <ref>PMID:9774669</ref> <ref>PMID:10648624</ref> <ref>PMID:12711603</ref> <ref>PMID:12665582</ref> <ref>PMID:12697822</ref> <ref>PMID:14610093</ref> <ref>PMID:15327775</ref> <ref>PMID:14555760</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Smith, B O]]
 [[Category: Thomson, R]]
-[[Category: Smith, B.O]]
+[[Category: Transcription]]