5dcy: Difference between revisions

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'''Unreleased structure'''
==Iridoid synthase G150A mutant from Catharanthus roseus - binary complex with NADP+==
<StructureSection load='5dcy' size='340' side='right' caption='[[5dcy]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5dcy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DCY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DCY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Iridoid_synthase Iridoid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.99 1.3.1.99] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dcy OCA], [http://pdbe.org/5dcy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dcy RCSB], [http://www.ebi.ac.uk/pdbsum/5dcy PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5beta-reductase are highlighted.


The entry 5dcy is ON HOLD  until Paper Publication
Structural determinants of reductive terpene cyclization in iridoid biosynthesis.,Kries H, Caputi L, Stevenson CE, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE Nat Chem Biol. 2015 Nov 9. doi: 10.1038/nchembio.1955. PMID:26551396<ref>PMID:26551396</ref>


Authors: Caputi, L., Kries, H., Stevenson, C.E.M., Kamileen, M.O., Sherden, N.H., Geu-Flores, F., Lawson, D.M., O'Connor, S.E.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description:
<div class="pdbe-citations 5dcy" style="background-color:#fffaf0;"></div>
[[Category: Unreleased Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Iridoid synthase]]
[[Category: Caputi, L]]
[[Category: Connor, S E.O]]
[[Category: Geu-Flores, F]]
[[Category: Kamileen, M O]]
[[Category: Kries, H]]
[[Category: Kries, H]]
[[Category: Geu-Flores, F]]
[[Category: Lawson, D M]]
[[Category: Sherden, N.H]]
[[Category: Sherden, N H]]
[[Category: Kamileen, M.O]]
[[Category: Stevenson, C E.M]]
[[Category: Stevenson, C.E.M]]
[[Category: Catharanthus roseus]]
[[Category: O'Connor, S.E]]
[[Category: Nadph-dependent]]
[[Category: Caputi, L]]
[[Category: Oxidoreductase]]
[[Category: Lawson, D.M]]
[[Category: Short chain dehydrogenase]]
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