1gio: Difference between revisions
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==Overview== | ==Overview== | ||
The three-dimensional structure of bovine angiogenin has been determined, using two- and three-dimensional proton NMR spectroscopy. The solution, structure is very close to that recently determined by X-ray diffraction, analysis. This structure appears well defined, even if five loops and one, helix exhibit greater flexibility. Analysis of the active site geometry, confirms the position of the Glu-118 residue which obstructs the, pyrimidine binding site. There is no experimental evidence of an, unobstructed conformation of angiogenin in solution. In addition, it, appears that the Glu-118 and Ser-119 residues and the cell receptor, binding loop may play an important role in the differences of C-terminal, fragment organization and ribonucleolytic activity observed between, angiogenins and . | The three-dimensional structure of bovine angiogenin has been determined, using two- and three-dimensional proton NMR spectroscopy. The solution, structure is very close to that recently determined by X-ray diffraction, analysis. This structure appears well defined, even if five loops and one, helix exhibit greater flexibility. Analysis of the active site geometry, confirms the position of the Glu-118 residue which obstructs the, pyrimidine binding site. There is no experimental evidence of an, unobstructed conformation of angiogenin in solution. In addition, it, appears that the Glu-118 and Ser-119 residues and the cell receptor, binding loop may play an important role in the differences of C-terminal, fragment organization and ribonucleolytic activity observed between, angiogenins and ribonuclease A. | ||
==About this Structure== | ==About this Structure== | ||
1GIO is a | 1GIO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Structure known Active Site: RIB. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GIO OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: hydrolase angiogenesis]] | [[Category: hydrolase angiogenesis]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:59:36 2007'' | ||
